AI Software & Applications,
Built for the Real World

iSyslab (Intelligent Systems Laboratory),Zhidong's Research Group at School of Software of HUST develops AI software and applications — pairing algorithm research with real-world scenarios in gaming, bioinformatics and healthcare.iSyslab(智能系统实验室)是在华中科技大学软件学院薛志东研究组的名称,致力于人工智能软件与应用研发,将算法研究与游戏、生物信息、医疗等真实场景紧密结合。

53
Publications
12
Software Tools
5
Research Areas
iSyslab Zhidong's Research Group @ HUST

Huazhong University of Science & Technology
Wuhan, China

RESEARCH

Research Interests

Five directions from large language models and VR to biological macromolecule software and AI security — from algorithms to usable systems.

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01 Large Language Models and Applications大模型技术与应用 大模型技术与应用Large Language Models and Applications

Language-model technology and agents — domain adaptation, RAG, hallucination control, and applications in knowledge QA, survey writing and education.语言模型与智能体技术——领域适配、检索增强、幻觉控制,落地知识问答、综述撰写与教育场景。

02 Virtual Reality and Computer Games虚拟现实与计算机游戏 虚拟现实与计算机游戏Virtual Reality and Computer Games

VR and serious games — immersive interaction, redirected walking, adaptive gameplay and quantitative assessment from motion data.虚拟现实与严肃游戏——沉浸交互、重定向行走、自适应玩法与基于运动数据的量化评估。

03 Image and Video Processing Technology图像与视频处理技术 图像与视频处理技术Image and Video Processing Technology

Visual computing for real acquisition scenarios — medical image analysis, detection and tracking, SLAM, video stitching and DNA-based image storage.面向真实采集场景的视觉计算——医学影像分析、检测与追踪、SLAM、视频拼接与 DNA 图像存储。

04 Biological Macromolecule Prediction and Software生物大分子预测与软件 生物大分子预测与软件Biological Macromolecule Prediction and Software

Computational prediction and software for proteins, peptides and RNA — structure, function and interactions, released as servers and open-source tools.蛋白质、多肽与 RNA 的计算预测与软件研发——结构、功能与相互作用,以服务器与开源工具发布。

05 AI Security and Privacy Protection人工智能安全与隐私保护 人工智能安全与隐私保护AI Security and Privacy Protection

Trustworthy AI — robustness and privacy of intelligent systems, content-risk detection, data-rights protection and LLM safety.可信人工智能——智能系统的鲁棒性与隐私、内容风险检测、数据权益保护与大模型安全。

NEWS

Latest News

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Oct 20262026年10月 Two national invention patents granted and ten papers published across 2025–20262025—2026 年获授权国家发明专利 2 项、发表论文 10 篇 Patent专利
Sep 20262026年9月 Seven 2026-intake graduate students join the lab — 23 current graduate students in total7 名 2026 级硕士研究生加入实验室,课题组在读研究生达 23 人 Life动态
Jul 20262026年7月 Lei WANG completed his postdoctoral term and joined Central China Normal University as Associate Research Professor王雷博士后出站,加入华中师范大学任特任副研究员 Life动态
Jul 20262026年7月 Hongyang YE joined the lab as a research assistant叶宏阳加入实验室担任研究助理 Life动态
SELECTED PUBLICATIONS

Selected Publications

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DeepNeuropePred: A robust and universal tool to predict cleavage sites from neuropeptide precursors by protein language model

Lei Wang#, Zilu Zeng#, Zhidong Xue*, and Yan Wang* · Computational and Structural Biotechnology Journal, 2024

Fueling ab initio folding with marine metagenomics enables structure and function predictions of new protein families

Yan Wang#, Qiang Shi#, Pengshuo Yang#, Chengxin Zhang#, S. M. Mortuza, Zhidong Xue*, Kang Ning*, and Yang Zhang* · Genome Biology, 2019

ThreaDomEx: a unified platform for predicting continuous and discontinuous protein domains by multiple-threading and segment assembly

Yan Wang, Jian Wang, Ruiming Li, Qiang Shi, Zhidong Xue*, and Yang Zhang* · Nucleic Acids Research, 2017

Join iSyslab

We recruit postdocs, master's & PhD students and undergraduate researchers year-round. Postdoc salary starts from RMB 200,000/year.

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