2026

An interpretable multimodal ensemble assessment framework for Alzheimer's disease cognitive staging

Jiale Zhang, Bo Yuan, Yaran Liu, and Zhidong Xue

17, 1911900

Frontiers in Neurology · 2026

ProtFormer-Site: Ultra-fast and Accurate Prediction of Protein-Protein Interaction Sites with Protein Language Model

Lei Wang, Shali Dong, Han Zhang, Yuchen Chen, Xudong Li, Yan Wang, and Zhidong Xue*

Interdisciplinary Sciences: Computational Life Sciences · 2026

SPLiNet: Lightweight prediction of protein-RNA interaction sites by integrating a structure-aware protein language model with a dual-branch network

Hongyang Ye, Changrong Zheng, Lei Wang, Yan Wang, and Zhidong Xue*

124(Pt 1), 109130

Computational Biology and Chemistry · 2026

Multimodal data fusion of dual-modal DWI-ADC MRI and clinical variables for prognostic prediction in acute ischemic stroke

Yanliang Ji, Xuewen Wo, Bo Yuan, Yaran Liu, and Zhidong Xue

17, 1849525

Frontiers in Neurology · 2026

2025

ProtSSSD: A Novel Approach for Intrinsically Disordered Protein Region Prediction Using Protein Language Model

Lei Wang, Zilu Zeng, Yan Wang, and Zhidong Xue

1860–1863

IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2025) · 2025

An Effective DNA Storage for Contour-Based Image

Chunxia Ge, Xiaosheng Dong, and Zhidong Xue

59–66

Bio-Inspired Computing: Theories and Applications (BIC-TA 2025) · Springer CCIS · 2025

Protein-Protein Contact Prediction Using Structure-Informed Sequences and Protein Language Models

Qiyuan Huang, Lei Wang, Zhihong Zhang, Jingjing Zhao, and Zhidong Xue

99–107

Bio-Inspired Computing: Theories and Applications (BIC-TA 2025) · Springer CCIS · 2025

Exploring ProtFlash: An Efficient Approach to Protein Data Analysis

Lei Wang, Zhidong Xue*, and Yan Wang

2941, 59–70

Methods in Molecular Biology · 2025

MS-Detector: A Hierarchical Deep Learning Method to Detect Muscle Strain Using Bilateral Symmetric Ultrasound Images of the Body

Le Zhu, Yifu Xiong, Huachao Wu, Li Zhu, Zihan Tang, Wenbin Pei, Jing Zhou, and Zhidong Xue

15(23), 3087

Diagnostics · 2025

High-precision screening of occupational chronic lead poisoning with machine-learning-enhanced LIBS高精度职业性慢性铅中毒筛查:机器学习增强的LIBS技术应用

Rui Zhang, Lizhu Kang, Zhijie Huang, Wenhao Yan, Zhanjian Lin, Ji Chen, Bing Lu, Zhidong Xue, and Xiangyou Li张蕊, 康丽珠, 黄智杰, 闫文豪, 林湛坚, 陈吉, 鲁兵, 薛志东, 李祥友

Spectroscopy and Spectral Analysis光谱学与光谱分析 (in Chinese)(中文) · 2025

2024

A universal oral microbiome-based signature for periodontitis

Mingyan Geng, Min Li, Yun Li, Jiaying Zhu, Chuqing Sun, Yan Wang, and Wei-Hua Chen*

3(4), e212

iMeta · 2024

NeuroPep 2.0: An Updated Database Dedicated to Neuropeptide and Its Receptor Annotations

Mingxia Wang#, Lei Wang#, Wei Xu, Ziqiang Chu, Hengzhi Wang, Jingxiang Lu, Zhidong Xue, and Yan Wang

436(4), 168416

Journal of Molecular Biology · 2024

DeepNeuropePred: A robust and universal tool to predict cleavage sites from neuropeptide precursors by protein language model

Lei Wang#, Zilu Zeng#, Zhidong Xue*, and Yan Wang*

23, 309–315

Computational and Structural Biotechnology Journal · 2024

2023

NeuroPred-PLM: An interpretable and robust model for neuropeptide prediction by protein language model

Lei Wang, Chen Huang, Mingxia Wang, Zhidong Xue*, and Yan Wang*

24(2), bbad077

Briefings in Bioinformatics · 2023

Deciphering the protein landscape with ProtFlash, a lightweight language model

Lei Wang, Hui Zhang, Wei Xu, Zhidong Xue*, and Yan Wang*

4(10), 101600

Cell Reports Physical Science · 2023

2022

Improving the topology prediction of α-helical transmembrane proteins with deep transfer learning

Lei Wang, Haolin Zhong, Zhidong Xue*, and Yan Wang*

20, 1993–2000

Computational and Structural Biotechnology Journal · 2022

Res-Dom: Predicting protein domain boundary from sequence using deep residual network and Bi-LSTM

Lei Wang, Haolin Zhong, Zhidong Xue*, and Yan Wang*

2(1), vbac060

Bioinformatics Advances · 2022

2021

Protein domain identification methods and online resources

Yan Wang, Hang Zhang, Haolin Zhong, and Zhidong Xue

19, 1145–1153

Computational and Structural Biotechnology Journal · 2021

Deep learning for mining protein data

Qiang Shi, Weiya Chen, Siqi Huang, Yan Wang*, and Zhidong Xue*

22(1), 194–218

Briefings in Bioinformatics · 2021

2020

Landscape of cancer diagnostic biomarkers from specifically expressed genes

Yao Lv, Sheng-Yan Lin, Fei-Fei Hu, Zheng Ye, Qiong Zhang, Yan Wang, and An-Yuan Guo*

21(6), 2175–2184

Briefings in Bioinformatics · 2020

A Survey on Hand Pose Estimation with Wearable Sensors and Computer-Vision-Based Methods

Weiya Chen, Chenchen Yu, Chenyu Tu, Zehua Lyu, Jing Tang, Shiqi Ou*, Yan Fu*, and Zhidong Xue*

20(4), 1074

Sensors · 2020

pmTM-align: Scalable pairwise and multiple structure alignment with Apache Spark and OpenMP

Weiya Chen, Chun Yao, Yingzhong Guo, Yan Wang, and Zhidong Xue

21(1), 426

BMC Bioinformatics · 2020

Research progress and applications of DNA cryptographyDNA密码学研究进展与应用

Xiaosheng Dong, Lei Wang, Yan Wang, and Zhidong Xue董校生, 王雷, 王燕, 薛志东

Journal of Guangzhou University (Natural Science Edition)广州大学学报(自然科学版) (in Chinese)(中文) · 2020

2019

Fueling ab initio folding with marine metagenomics enables structure and function predictions of new protein families

Yan Wang#, Qiang Shi#, Pengshuo Yang#, Chengxin Zhang#, S. M. Mortuza, Zhidong Xue*, Kang Ning*, and Yang Zhang*

20(1), 229

Genome Biology · 2019

DNN-Dom: predicting protein domain boundary from sequence alone by deep neural network

Qiang Shi, Weiya Chen, Siqi Huang, Fanglin Jin, Yinghao Dong, Yan Wang*, and Zhidong Xue*

35(24), 5128–5136

Bioinformatics · 2019

A review of protein domain identification methods and online resources蛋白质结构域划分方法及在线服务综述

Yan Wang, Qiang Shi, and Zhidong Xue王燕, 石强, 薛志东

Journal of Guangzhou University (Natural Science Edition)广州大学学报(自然科学版) (in Chinese)(中文) · 2019

DNA computing: current status and prospectsDNA计算的研究现状与展望

Qiang Shi, Yan Wang, Wei Xiao, Xiaolong Shi, and Zhidong Xue石强, 王燕, 肖玮, 石晓龙, 薛志东

Journal of Guangzhou University (Natural Science Edition)广州大学学报(自然科学版) (in Chinese)(中文) · 2019

2018

Evaluation of Lightweight Local Descriptors for Level Ground Navigation with Monocular SLAM

Weiya Chen, Yulin Wan, Shiqi Ou, and Zhidong Xue

347–358

Chinese Conference on Pattern Recognition and Computer Vision (PRCV 2018) · Springer LNCS 11259 · 2018

An Automatic Classification Method on Chronic Venous Insufficiency Images

Qiang Shi#, Weiya Chen#, Ye Pan, Shan Yin, Yan Fu, Jiacai Mei*, and Zhidong Xue*

8(1), 17952

Scientific Reports · 2018

StraPep: A Structure Database of Bioactive Peptides

Jian Wang#, Tailang Yin#, Xuwen Xiao, Dan He, Zhidong Xue, Xinnong Jiang*, and Yan Wang*

2018, bay038

Database: The Journal of Biological Databases and Curation · 2018

2017

ThreaDomEx: a unified platform for predicting continuous and discontinuous protein domains by multiple-threading and segment assembly

Yan Wang, Jian Wang, Ruiming Li, Qiang Shi, Zhidong Xue*, and Yang Zhang*

45(W1), W400–W407

Nucleic Acids Research · 2017

I-TASSER-MR: automated molecular replacement for distant-homology proteins using iterative fragment assembly and progressive sequence truncation

Yan Wang, Jouko Virtanen, Zhidong Xue*, and Yang Zhang*

45(W1), W429–W434

Nucleic Acids Research · 2017

2016

Using iterative fragment assembly and progressive sequence truncation to facilitate phasing and crystal structure determination of distantly related proteins

Yan Wang, Jouko Virtanen, Zhidong Xue, John J. G. Tesmer, and Yang Zhang

72(5), 616–628

Acta Crystallographica Section D: Structural Biology · 2016

ResQ: An Approach to Unified Estimation of B-Factor and Residue-Specific Error in Protein Structure Prediction

Jianyi Yang, Yan Wang, and Yang Zhang*

428(4), 693–701

Journal of Molecular Biology · 2016

2015

Extending Protein Domain Boundary Predictors to Detect Discontinuous Domains

Zhidong Xue*, Richard Jang, Brandon Govindarajoo, Yichu Huang, and Yan Wang*

10(10), e0141541

PLOS ONE · 2015

NMR data-driven structure determination using NMR-I-TASSER in the CASD-NMR experiment

Richard Jang, Yan Wang, Zhidong Xue*, and Yang Zhang*

62(4), 511–525

Journal of Biomolecular NMR · 2015

NeuroPep: A comprehensive resource of neuropeptides

Yan Wang, Mingxia Wang, Sanwen Yin, Richard Jang, Jian Wang, Zhidong Xue*, and Tao Xu*

2015, bav038

Database: The Journal of Biological Databases and Curation · 2015

2009

A Steplike Stacking Heuristic Algorithm for Solving Rectangle Packing Problem

Shi Wang and Zhidong Xue

3, 1–4

International Conference on Information Engineering and Computer Science (ICIECS 2009) · IEEE · 2009

Protein structure prediction based on the Hamiltonian path model基于Hamilton路模型的蛋白质结构预测的研究

Xiaohong Shi, Xinjuan Jia, and Yan Wang史小红, 贾新娟, 王燕

Mathematics in Practice and Theory数学的实践与认识 (in Chinese)(中文) · 2009

2008

PRINTR: Prediction of RNA binding sites in proteins using SVM and profiles

Y. Wang, Z. Xue, G. Shen, and J. Xu

35(2), 295–302

Amino Acids · 2008

2007

An SVM image segmentation method with training-sample selection一种结合训练样本筛选的SVM图像分割方法

Zhidong Xue, Yan Wang, and Weiping Sui薛志东, 王燕, 隋卫平

Computer Engineering and Applications计算机工程与应用 (in Chinese)(中文) · 2007

A study of SVM-based image segmentation methodsSVM图像分割方法的研究

Zhidong Xue, Yan Wang, and Lijun Li薛志东, 王燕, 李利军

Microcomputer Information微计算机信息 (in Chinese)(中文) · 2007

A sample-selection method for inverse C-means learning逆C均值学习样本筛选方法

Zhidong Xue, Yan Wang, and Dehong Qiu薛志东, 王燕, 邱德红

Microcomputer Information微计算机信息 (in Chinese)(中文) · 2007

An image segmentation method combining SVM and region growing一种SVM与区域生长相结合的图像分割方法

Zhidong Xue, Weiping Sui, and Lijun Li薛志东, 隋卫平, 李利军

Journal of Computer Applications计算机应用 (in Chinese)(中文) · 2007

Prediction of generalized alpha-turns广义α转角的预测研究

Yan Wang, Zhidong Xue, Xiaohong Shi, and Jin Xu王燕, 薛志东, 史小红, 许进

Journal of Huazhong University of Science and Technology (Natural Science Edition)华中科技大学学报(自然科学版) (in Chinese)(中文) · 2007

A multi-class SVM segmentation method for virtual-human slice data分割虚拟人切片数据的SVM多类分割方法

Zhidong Xue, Weiping Sui, and Lijun Li薛志东, 隋卫平, 李利军

Application Research of Computers计算机应用研究 (in Chinese)(中文) · 2007

2006

Prediction of pi-turns in proteins using PSI-BLAST profiles and secondary structure information

Yan Wang, Zhidong Xue, Xiaohong Shi, and Jin Xu

347(3), 574–580

Biochemical and Biophysical Research Communications · 2006

Better prediction of the location of alpha-turns in proteins with support vector machine

Yan Wang, Zhidong Xue, and Jin Xu

65(1), 49–54

Proteins: Structure, Function, and Bioinformatics · 2006

Automatic segmentation of color virtual-human slice images based on SVM基于SVM的虚拟人彩色切片图像自动分割

Zhidong Xue, Lijun Li, Dehong Qiu, and Cheng Wang薛志东, 李利军, 邱德红, 王乘

Journal of Huazhong University of Science and Technology (Natural Science Edition)华中科技大学学报(自然科学版) (in Chinese)(中文) · 2006

A hybrid method for segmenting color frozen virtual-human slice images一种分割虚拟人彩色冰冻切片图像的混和方法

Zhidong Xue, Weiping Sui, and Cheng Wang薛志东, 隋卫平, 王乘

Computer Engineering & Science计算机工程与科学 (in Chinese)(中文) · 2006

Segmenting virtual-human slice data with support vector machines利用支持向量机分割虚拟人切片数据

Zhidong Xue, Lijun Li, Zhongyi Li, and Cheng Wang薛志东, 李利军, 李衷怡, 王乘

Application Research of Computers计算机应用研究 (in Chinese)(中文) · 2006

2002

Improving the parallel computing capability of ARC/INFO with CORBA用CORBA提高ARC/INFO的并行计算能力

Zhidong Xue and Duoqiang Wang薛志东, 王多强

Computer and Digital Engineering计算机与数字工程 (in Chinese)(中文) · 2002

2001

Dynamic scheduling strategies in distributed computing systems分布式计算系统中的动态调度策略研究

Duoqiang Wang, Jianbin Wei, Zhiyong Chen, and Zhidong Xue王多强, 魏建宾, 陈志勇, 薛志东

Journal of Huazhong University of Science and Technology (Natural Science Edition)华中科技大学学报(自然科学版) (in Chinese)(中文) · 2001