Bioactive peptide information

BP1249

Name

Tumor necrosis factor ligand superfamily member 10

Organism

Homo sapiens

Family

tumor necrosis factor family

Classification

Cytokine/Growth factor

UniProt ID

TNF10_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0070062	Cellular Component	extracellular exosome	IDA
GO:0005576	Cellular Component	extracellular region	TAS
GO:0005615	Cellular Component	extracellular space	IEA
GO:0005887	Cellular Component	integral component of plasma membrane	TAS
GO:0046872	Molecular Function	metal ion binding	IEA	more>>
GO:0005102	Molecular Function	receptor binding	TAS
GO:0006919	Biological Process	activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS
GO:0097296	Biological Process	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	TAS
GO:0006915	Biological Process	apoptotic process	TAS
GO:0007166	Biological Process	cell surface receptor signaling pathway	TAS
GO:0007267	Biological Process	cell-cell signaling	TAS
GO:0006955	Biological Process	immune response	IEA
GO:0008584	Biological Process	male gonad development	IEA
GO:1902042	Biological Process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS
GO:0043065	Biological Process	positive regulation of apoptotic process	IDA
GO:0043280	Biological Process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA
GO:2001238	Biological Process	positive regulation of extrinsic apoptotic signaling pathway	IDA
GO:0043123	Biological Process	positive regulation of I-kappaB kinase/NF-kappaB signaling	IEP
GO:0090200	Biological Process	positive regulation of release of cytochrome c from mitochondria	IDA
GO:1902041	Biological Process	regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS
GO:0032868	Biological Process	response to insulin	IEA
GO:0007165	Biological Process	signal transduction	TAS	less<<

Modification

Length

168

Sequence

VRERGPQRVA  AHITGTRGRS  NTLSSPNSKN  EKALGRKINS  WESSRSGHSF  LSNLHLRNGE  LVIHEKGFYY
IYSQTYFRFQ  EEIKENTKND  KQMVQYIYKY  TSYPDPILLM  KSARNSCWSK  DAEYGLYSIY  QGGIFELKEN
DRIFVSVTNE  HLIDMDHEAS  FFGAFLVG

Properties

View

Structure

PDB	Method	Resolution	Chain	Position
1D0G	X-ray	2.40 A	A/B/D	1-168
1D2Q	X-ray	2.80 A	A/B	1-168
1D4V	X-ray	2.20 A	B	6-168
1DG6	X-ray	1.30 A	A	1-168
1DU3	X-ray	2.20 A	D/E/F/J/K/L	1-168
4N90	X-ray	3.30 A	A/B/C	1-168
5CIR	X-ray	3.00 A	A/B/D	1-168
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 1.79%

Beta strand (B, E): 46.43%

Turn (S, T): 17.26%

Coil (C): 34.52%

1    VRERGPQRVA  AHITGTRGRS  NTLSSPNSKN  EKALGRKINS  WESSRSGHSF  LSNLHLRNGE
              E  EEEE                      SSSEE      B BTTTTBE  EESEEEETTE
61   LVIHEKGFYY  IYSQTYFRFQ  EEIKENTKND  KQMVQYIYKY  TSYPDPILLM  KSARNSCWSK
     EEESS EEEE  EEEEEEEEE       TTS      EEEEEEEEE   SSSS EEEE  EEEEE    T
121  DAEYGLYSIY  QGGIFELKEN  DRIFVSVTNE  HLIDMDHEAS  FFGAFLVG
     T   EEEEEE  EEEEEEE TT   EEEEEESSG  GGB   TTTS  EEEEEE

Pfam

Accession NO.	Identifier	Description
PF00229	TNF	TNF(Tumour Necrosis Factor) family

SCOP

Class	Fold	Superfamily	Family
All beta proteins	TNF-like	TNF-like	TNF-like

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Sandwich	Jelly Rolls