Bioactive peptide information

BP1046

Name

Interleukin-36 receptor antagonist protein

Organism

Homo sapiens

Family

IL-1 family

Classification

Cytokine/Growth factor

UniProt ID

I36RA_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005615	Cellular Component	extracellular space	IBA
GO:0005125	Molecular Function	cytokine activity	IBA
GO:0005152	Molecular Function	interleukin-1 receptor antagonist activity	TAS
GO:0005149	Molecular Function	interleukin-1 receptor binding	IBA
GO:0019732	Biological Process	antifungal humoral response	IMP	more>>
GO:0045087	Biological Process	innate immune response	IEA
GO:0001960	Biological Process	negative regulation of cytokine-mediated signaling pathway	IMP
GO:1902714	Biological Process	negative regulation of interferon-gamma secretion	IMP
GO:0032700	Biological Process	negative regulation of interleukin-17 production	IMP
GO:0032715	Biological Process	negative regulation of interleukin-6 production	IEA	less<<

Modification

Length

154

Sequence

VLSGALCFRM  KDSALKVLYL  HNNQLLAGGL  HAGKVIKGEE  ISVVPNRWLD  ASLSPVILGV  QGGSQCLSCG
VGQEPTLTLE  PVNIMELYLG  AKESKSFTFY  RRDMGLTSSF  ESAAYPGWFL  CTVPEADQPV  RLTQLPENGG
WNAPITDFYF  QQCD

Properties

View

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
4P0J	X-ray	2.30 A	A/B	1-134,146-154
4P0K	X-ray	1.70 A	A	1-48,54-134,146-154
4P0L	X-ray	1.55 A	A	1-48,54-134,146-154
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 7.33%

Beta strand (B, E): 40.00%

Turn (S, T): 26.67%

Coil (C): 26.00%

1    SLSGALCFRM  KDSALKVLYL  HNNQLLAGGL  HAGKVIKGEE  ISVVPNRWLD  ASLSPVILGV
           EEEE  EETT  EEEE  SSS EEEE S  S SS        EEEEE TTS   GGG EEEEEE
61   QGGSQCLSCG  VGQEPTLTLE  PVNIMELYLG  AKESKSFTFY  RRDMGLTSSF  ESAAYPGWFL
     TTTTEEEE    SSSS   EEE  S  HHHHHTT  SS  GGGEEE  EEEETTEEEE  EESSSTT EE
121  CTVPEADQPV  RLTQELGKSY  NTDFYFQQCD
     EB SSTTEE   EEES  STT   B  EEEEE

Pfam

Accession NO.	Identifier	Description
PF00340	IL1	Interleukin-1 / 18

SCOP

CATH