Bioactive peptide information

BP1019

Name

Pleiotrophin

Organism

Homo sapiens

Family

pleiotrophin family

Classification

Cytokine/Growth factor

UniProt ID

PTN_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005604	Cellular Component	basement membrane	IEA
GO:0009986	Cellular Component	cell surface	IEA
GO:0005783	Cellular Component	endoplasmic reticulum	IDA
GO:0005615	Cellular Component	extracellular space	TAS
GO:0016020	Cellular Component	membrane	IEA	more>>
GO:0031594	Cellular Component	neuromuscular junction	IEA
GO:0048471	Cellular Component	perinuclear region of cytoplasm	IEA
GO:1904399	Molecular Function	heparan sulfate binding	IEA
GO:0008201	Molecular Function	heparin binding	IEA
GO:0004864	Molecular Function	protein phosphatase inhibitor activity	TAS
GO:0030282	Biological Process	bone mineralization	IEA
GO:0071456	Biological Process	cellular response to hypoxia	IEA
GO:0036120	Biological Process	cellular response to platelet-derived growth factor stimulus	IEA
GO:0034644	Biological Process	cellular response to UV	IEA
GO:0071305	Biological Process	cellular response to vitamin D	IEA
GO:0021549	Biological Process	cerebellum development	IEA
GO:0045446	Biological Process	endothelial cell differentiation	IEA
GO:0044849	Biological Process	estrous cycle	IEA
GO:0007507	Biological Process	heart development	IEA
GO:0007612	Biological Process	learning	IEA
GO:0001889	Biological Process	liver development	IEA
GO:0060291	Biological Process	long-term synaptic potentiation	IEA
GO:0030324	Biological Process	lung development	IEA
GO:0016525	Biological Process	negative regulation of angiogenesis	IEA
GO:0030336	Biological Process	negative regulation of cell migration	IEA
GO:0050680	Biological Process	negative regulation of epithelial cell proliferation	IEA
GO:0060253	Biological Process	negative regulation of glial cell proliferation	IEA
GO:0045837	Biological Process	negative regulation of membrane potential	IEA
GO:0072201	Biological Process	negative regulation of mesenchymal cell proliferation	IEA
GO:1904397	Biological Process	negative regulation of neuromuscular junction development	IEA
GO:0007399	Biological Process	nervous system development	TAS
GO:0043065	Biological Process	positive regulation of apoptotic process	IEA
GO:0051781	Biological Process	positive regulation of cell division	IEA
GO:0008284	Biological Process	positive regulation of cell proliferation	TAS
GO:0010811	Biological Process	positive regulation of cell-substrate adhesion	IEA
GO:2000347	Biological Process	positive regulation of hepatocyte proliferation	IEA
GO:0010976	Biological Process	positive regulation of neuron projection development	IEA
GO:1904395	Biological Process	positive regulation of skeletal muscle acetylcholine-gated channel clustering	IEA
GO:0008360	Biological Process	regulation of cell shape	IEA
GO:0014823	Biological Process	response to activity	IEA
GO:1904391	Biological Process	response to ciliary neurotrophic factor	IEA
GO:0042493	Biological Process	response to drug	IEA
GO:0032355	Biological Process	response to estradiol	IEA
GO:1904373	Biological Process	response to kainic acid	IEA
GO:1990089	Biological Process	response to nerve growth factor	IEA
GO:0032570	Biological Process	response to progesterone	IEA
GO:0060221	Biological Process	retinal rod cell differentiation	IEA
GO:1904389	Biological Process	rod bipolar cell differentiation	IEA
GO:0021510	Biological Process	spinal cord development	IEA
GO:0021794	Biological Process	thalamus development	IEA
GO:0007185	Biological Process	transmembrane receptor protein tyrosine phosphatase signaling pathway	TAS	less<<

Modification

Length

136

Sequence

GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ
FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD

Properties

View

Disulfide bond

Structure

DSSP

Helix (H, G, I): 0.00%

Beta strand (B, E): 31.62%

Turn (S, T): 25.74%

Coil (C): 42.65%

1    GKKEKPEKKV  KKSDCGEWQW  SVCVPTSGDC  GLGTREGTRT  GAECKQTMKT  QRCKIPCNWK
       S          SS  EEEEE     B   SSS     EEEEEEE   TT  EEEEE  EE     SS
61   KQFGAECKYQ  FQAWGECDLN  TALKTRTGSL  KRALHNAECQ  KTVTISKPCG  KLTKPKPQAE
     S   SSSEEE  EE SS  BTT  TTEEEEEEEE  EE  SS      SEEEEEEESS       SS
121  SKKKKKEGKK  QEKMLD
       TTSS      TTTT

Pfam

Accession NO.	Identifier	Description
PF05196	PTN_MK_N	PTN/MK heparin-binding protein family, N-terminal domain

SCOP

CATH