Bioactive peptide information

BP1007

Name

Hirudin variant-1

Organism

Hirudo medicinalis

Family

protease inhibitor I14 (hirudin) family

Classification

Other

UniProt ID

HIRV1_HIRME

GO ID	GO Term	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	IEA
GO:0004867	Molecular Function	serine-type endopeptidase inhibitor activity	IEA

Modification

Modification	Residue	Position
Sulfotyrosine	Tyr	63

Length

Sequence

VVYTDCTESG QNLCLCEGSN VCGQGNKCIL GSDGEKNQCV TGEGTPKPQS HNDGDFEEIP EEYLQ

Properties

View

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
1AD8	X-ray	2.00 A	I	55-64
1AE8	X-ray	2.00 A	I	55-64
1AFE	X-ray	2.00 A	I	55-64
1AHT	X-ray	1.60 A	I	55-64
1AI8	X-ray	1.85 A	I	55-64
1AWF	X-ray	2.20 A	I	55-64
1AY6	X-ray	1.80 A	I	55-64
1BA8	X-ray	1.80 A	C	53-64
1BB0	X-ray	2.10 A	C	53-64
1BCU	X-ray	2.00 A	I	54-65
1CA8	X-ray	2.10 A	C	53-64
1D3D	X-ray	2.04 A	H	54-65
1D3P	X-ray	2.10 A	H	54-65
1D3Q	X-ray	2.90 A	H	54-65
1D3T	X-ray	3.00 A	H	54-65
1D4P	X-ray	2.07 A	H	54-65
1H8D	X-ray	1.40 A	I	55-64
1H8I	X-ray	1.75 A	I	55-64
1HIC	NMR	-	A	1-51
1HRT	X-ray	2.80 A	I	1-65
1HXE	X-ray	2.10 A	I	55-64
1HXF	X-ray	2.10 A	I	55-64
1NO9	X-ray	1.90 A	I	55-65
1QHR	X-ray	2.20 A	I	55-64
1QJ1	X-ray	2.00 A	I	55-64
1QJ6	X-ray	2.20 A	I	55-64
1QJ7	X-ray	2.20 A	I	55-64
1TMT	X-ray	2.20 A	I	53-65
1TMU	X-ray	2.50 A	J	55-65
1UMA	X-ray	2.00 A	I	55-64
1WBG	X-ray	2.20 A	I	55-64
2HIR	NMR	-	A	1-65
2JOO	NMR	-	A	1-65
2PW8	X-ray	1.84 A	I	3-65
2UUF	X-ray	1.26 A	H	55-64
2UUJ	X-ray	1.32 A	H	55-64
2UUK	X-ray	1.39 A	H	55-64
2V3O	X-ray	1.79 A	I	56-65
2ZC9	X-ray	1.58 A	I	54-64
2ZDA	X-ray	1.73 A	I	54-64
2ZDV	X-ray	1.72 A	I	54-64
2ZF0	X-ray	2.20 A	I	54-64
2ZFF	X-ray	1.47 A	I	54-64
2ZFP	X-ray	2.25 A	I	54-64
2ZGB	X-ray	1.60 A	I	54-64
2ZGX	X-ray	1.80 A	I	54-64
2ZHQ	X-ray	1.96 A	I	54-64
2ZI2	X-ray	1.65 A	I	54-64
2ZIQ	X-ray	1.65 A	I	54-64
2ZNK	X-ray	1.80 A	I	54-64
2ZO3	X-ray	1.70 A	I	54-64
3D49	X-ray	1.50 A	I	54-64
3DHK	X-ray	1.73 A	I	54-64
3DT0	X-ray	2.40 A	I	54-64
3DUX	X-ray	1.60 A	I	54-64
3EGK	X-ray	2.20 A	I	54-64
3EQ0	X-ray	1.53 A	I	54-64
3LDX	X-ray	2.25 A	I	55-65
3UTU	X-ray	1.55 A	I	54-64
4AX9	X-ray	1.90 A	I	55-65
4BAH	X-ray	1.94 A	D	53-64
4BAK	X-ray	1.94 A	D	53-64
4BAM	X-ray	1.88 A	D	53-64
4BAN	X-ray	1.87 A	D	53-64
4BAQ	X-ray	1.89 A	D	53-64
4HIR	NMR	-	A	1-65
4LXB	X-ray	1.61 A	I	53-65
4MLF	X-ray	2.20 A	D	1-65
4YES	X-ray	1.50 A	H	54-65
5HIR	NMR	-	A	1-65
6HIR	NMR	-	A	1-65
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DSSP

Helix (H, G, I): 0.00%

Beta strand (B, E): 23.08%

Turn (S, T): 24.62%

Coil (C): 52.31%

1    VVYTDCTESG  QNLCLCEGSN  VCGQGNKCIL  GSDGEKNQCV  TGEGTPKPQS  HNDGDFEEIP
      EE B  STT    SEE SSS   EE TTEEEE     TT   EEE  ES             S
61   EEYLQ
     STT

Pfam

Accession NO.	Identifier	Description
PF00713	Hirudin	Hirudin

SCOP

Class	Fold	Superfamily	Family
Small proteins	Knottins (small inhibitors, toxins, lectins)	Leech antihemostatic proteins	Hirudin-like

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Distorted Sandwich	Thrombin Inhibitor (Hirudin); Chain I	Thrombin Inhibitor (Hirudin), subunit I