Bioactive peptide information

BP0995

Name

Islet amyloid polypeptide

Organism

Homo sapiens

Family

calcitonin family

Classification

Hormone

UniProt ID

GO ID	GO Term	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	TAS
GO:0005615	Cellular Component	extracellular space	IEA
GO:0043025	Cellular Component	neuronal cell body	IEA
GO:0042802	Molecular Function	identical protein binding	IPI
GO:0005102	Molecular Function	receptor binding	TAS	more>>
GO:0006915	Biological Process	apoptotic process	TAS
GO:0007267	Biological Process	cell-cell signaling	TAS
GO:0044267	Biological Process	cellular protein metabolic process	TAS
GO:0042755	Biological Process	eating behavior	IEA
GO:0031018	Biological Process	endocrine pancreas development	TAS
GO:0045779	Biological Process	negative regulation of bone resorption	IEA
GO:0045596	Biological Process	negative regulation of cell differentiation	IEA
GO:0019233	Biological Process	sensory perception of pain	IEA
GO:0007165	Biological Process	signal transduction	TAS	less<<

Modification

Modification	Residue	Position
Tyrosine amide	Tyr	37

Length

Sequence

KCNTATCATQ RLANFLVHSS NNFGAILSST NVGSNTY

Properties

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
1KUW	NMR	-	A	20-29
2G48	X-ray	2.60 A	C/D	1-37
2KB8	NMR	-	A	1-37
2L86	NMR	-	A	1-37
3DG1	X-ray	1.66 A	A	28-33
3FPO	X-ray	1.50 A	A	18-23
3FR1	X-ray	1.85 A	A	14-19
3FTH	X-ray	1.84 A	A/B	14-20
3FTK	X-ray	1.50 A	A	31-37
3FTL	X-ray	1.60 A	A/B	31-37
3FTR	X-ray	1.61 A	A	28-33
3G7V	X-ray	1.86 A	A/B/C/D	1-36
3G7W	X-ray	1.75 A	A	1-22
3HGZ	X-ray	2.91 A	D/E	1-37
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DSSP

Helix (H, G, I): 8.11%

Beta strand (B, E): 8.11%

Turn (S, T): 5.41%

Coil (C): 78.38%

1 KCNTATCATQ RLANFLVHSS NNFGAILSST NVGSNTY
BGGG EESS

Pfam

Accession NO.	Identifier	Description
PF00214	Calc_CGRP_IAPP	Calcitonin / CGRP / IAPP family

SCOP

CATH