Bioactive peptide information

BP0992

Name

Griffithsin

Organism

Griffithsia sp.

Family

jacalin lectin family

Classification

Antimicrobial

UniProt ID

GRFIN_GRISQ

GO ID	GO Term	Definition	Evidence
GO:0005623	Cellular Component	cell	IDA
GO:0030246	Molecular Function	carbohydrate binding	IDA
GO:0005536	Molecular Function	glucose binding	IDA
GO:0005537	Molecular Function	mannose binding	IDA
GO:0046871	Molecular Function	N-acetylgalactosamine binding	IDA

Modification

Length

121

Sequence

SLTHRKFGGS GGSPFSGLSS IAVRSGSYLD XIIIDGVHHG GSGGNLSPTF TFGSGEYISN MTIRSGDYID
NISFETNMGR RFGPYGGSGG SANTLSNVKV IQINGSAGDY LDSLDIYYEQ Y

Properties

View

Structure

PDB	Method	Resolution	Chain	Position
2GTY	X-ray	1.30 A	A/B	1-121
2GUC	X-ray	1.79 A	A/B	1-121
2GUD	X-ray	0.94 A	A/B	1-121
2GUE	X-ray	2.02 A	A/B	1-121
2GUX	X-ray	2.00 A	A	1-121
2HYQ	X-ray	2.00 A	A/B	1-121
2HYR	X-ray	1.51 A	A/B	1-121
2NU5	X-ray	1.56 A	A/B	1-121
2NUO	X-ray	1.50 A	A/B	1-121
3LKY	X-ray	1.11 A	A	1-121
3LL0	X-ray	1.70 A	A	1-121
3LL1	X-ray	0.97 A	A	1-119
3LL2	X-ray	0.97 A	A	1-121
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DSSP

Helix (H, G, I): 0.00%

Beta strand (B, E): 63.93%

Turn (S, T): 19.67%

Coil (C): 16.39%

1    XSLTHRKFGG  SGGSPFSGLS  SIAVRSGSYL  DAIIIDGVHH  GGSGGNLSPT  FTFGSGEYIS
       EEEEEEE   S SEEE S    EEEEEESSSE  EEEEETTEEE  E S SEE     EE  TT  EE
61   NMTIRSGDYI  DNISFETNMG  RRFGPYGGSG  GSANTLSNVK  VIQINGSAGD  YLDSLDIYYE
     EEEEEESSSE  EEEEEEETTS   EEEEEE S   SEEEEEESEE  EEEEEEEESS  SEEEEEEEEE
121  QY
     E

Pfam

Accession NO.	Identifier	Description
PF01419	Jacalin	Jacalin-like lectin domain

SCOP

Class	Fold	Superfamily	Family
All beta proteins	beta-Prism I	Mannose-binding lectins	Mannose-binding lectins

CATH