Bioactive peptide information

BP0985

Name

Glucagon

Organism

Homo sapiens

Family

glucagon family

Classification

Hormone

UniProt ID

GLUC_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005788	Cellular Component	endoplasmic reticulum lumen	TAS
GO:0005576	Cellular Component	extracellular region	TAS
GO:0005615	Cellular Component	extracellular space	IBA
GO:0005886	Cellular Component	plasma membrane	TAS
GO:0034774	Cellular Component	secretory granule lumen	TAS	more>>
GO:0031769	Molecular Function	glucagon receptor binding	IBA
GO:0005179	Molecular Function	hormone activity	IBA
GO:0042802	Molecular Function	identical protein binding	IPI
GO:0005102	Molecular Function	receptor binding	TAS
GO:0007188	Biological Process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IBA
GO:0008283	Biological Process	cell proliferation	TAS
GO:0044267	Biological Process	cellular protein metabolic process	TAS
GO:0071377	Biological Process	cellular response to glucagon stimulus	TAS
GO:0006112	Biological Process	energy reserve metabolic process	TAS
GO:0007631	Biological Process	feeding behavior	TAS
GO:0007186	Biological Process	G-protein coupled receptor signaling pathway	TAS
GO:0043066	Biological Process	negative regulation of apoptotic process	IBA
GO:0032099	Biological Process	negative regulation of appetite	IEA
GO:1900118	Biological Process	negative regulation of execution phase of apoptosis	IEA
GO:2001243	Biological Process	negative regulation of intrinsic apoptotic signaling pathway	IEA
GO:0090280	Biological Process	positive regulation of calcium ion import	IEA
GO:0030819	Biological Process	positive regulation of cAMP biosynthetic process	IEA
GO:0070374	Biological Process	positive regulation of ERK1 and ERK2 cascade	IEA
GO:0035948	Biological Process	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter	IEA
GO:0051571	Biological Process	positive regulation of histone H3-K4 methylation	IEA
GO:0035774	Biological Process	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IBA
GO:0033138	Biological Process	positive regulation of peptidyl-serine phosphorylation	IEA
GO:0010800	Biological Process	positive regulation of peptidyl-threonine phosphorylation	IEA
GO:0032092	Biological Process	positive regulation of protein binding	IEA
GO:0045860	Biological Process	positive regulation of protein kinase activity	IEA
GO:0010737	Biological Process	protein kinase A signaling	IBA
GO:0050796	Biological Process	regulation of insulin secretion	TAS
GO:0042594	Biological Process	response to starvation	IBA
GO:0007165	Biological Process	signal transduction	TAS
GO:0044281	Biological Process	small molecule metabolic process	TAS	less<<

Modification

Modification	Residue	Position
Phosphoserine	Ser	2

Length

Sequence

HSQGTFTSDY SKYLDSRRAQ DFVQWLMNT

Properties

View

Structure

PDB	Method	Resolution	Chain	Position
1BH0	X-ray	3.00 A	A	1-29
2G49	X-ray	2.50 A	C/D	1-29
2M5P	NMR	-	X	1-29
2M5Q	NMR	-	X	1-29
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 51.72%

Beta strand (B, E): 0.00%

Turn (S, T): 31.03%

Coil (C): 17.24%

1 HSQGTFTSDY SKYLDSKKAQ EFVQWLMNT
S SSTTTT HHHHHHHHHH HHHHHTT

Pfam

Accession NO.	Identifier	Description
PF00123	Hormone_2	Peptide hormone

SCOP

Class	Fold	Superfamily	Family
Peptides	Peptide hormones	Peptide hormones	Peptide hormones

CATH