Bioactive peptide information

BP0978

Name

RANTES(3-68)

Organism

Homo sapiens

Family

intercrine beta (chemokine CC) family

Classification

Cytokine/Growth factor

UniProt ID

CCL5_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005737	Cellular Component	cytoplasm	IEA
GO:0005576	Cellular Component	extracellular region	TAS
GO:0005615	Cellular Component	extracellular space	IBA
GO:0031726	Molecular Function	CCR1 chemokine receptor binding	IPI
GO:0031729	Molecular Function	CCR4 chemokine receptor binding	TAS	more>>
GO:0031730	Molecular Function	CCR5 chemokine receptor binding	IPI
GO:0042056	Molecular Function	chemoattractant activity	IDA
GO:0008009	Molecular Function	chemokine activity	NAS
GO:0046817	Molecular Function	chemokine receptor antagonist activity	IDA
GO:0042379	Molecular Function	chemokine receptor binding	IPI
GO:0008201	Molecular Function	heparin binding	IEA
GO:0004435	Molecular Function	phosphatidylinositol phospholipase C activity	IDA
GO:0016004	Molecular Function	phospholipase activator activity	IDA
GO:0042803	Molecular Function	protein homodimerization activity	IDA
GO:0004672	Molecular Function	protein kinase activity	IDA
GO:0043621	Molecular Function	protein self-association	IDA
GO:0030298	Molecular Function	receptor signaling protein tyrosine kinase activator activity	IDA
GO:0031584	Biological Process	activation of phospholipase D activity	IDA
GO:0007568	Biological Process	aging	IEA
GO:0006816	Biological Process	calcium ion transport	IDA
GO:0007267	Biological Process	cell-cell signaling	IDA
GO:0006874	Biological Process	cellular calcium ion homeostasis	IDA
GO:0043623	Biological Process	cellular protein complex assembly	IDA
GO:0071448	Biological Process	cellular response to alkyl hydroperoxide	IEA
GO:0071230	Biological Process	cellular response to amino acid stimulus	IEA
GO:0071361	Biological Process	cellular response to ethanol	IEA
GO:0044344	Biological Process	cellular response to fibroblast growth factor stimulus	IEP
GO:0071403	Biological Process	cellular response to high density lipoprotein particle stimulus	IEA
GO:0071346	Biological Process	cellular response to interferon-gamma	IEP
GO:0071347	Biological Process	cellular response to interleukin-1	IEP
GO:0071315	Biological Process	cellular response to morphine	IEA
GO:0071407	Biological Process	cellular response to organic cyclic compound	IDA
GO:0071560	Biological Process	cellular response to transforming growth factor beta stimulus	IEA
GO:0071356	Biological Process	cellular response to tumor necrosis factor	IEP
GO:0071307	Biological Process	cellular response to vitamin K	IEA
GO:0070098	Biological Process	chemokine-mediated signaling pathway	IDA
GO:0006935	Biological Process	chemotaxis	NAS
GO:0002544	Biological Process	chronic inflammatory response	IEA
GO:0002407	Biological Process	dendritic cell chemotaxis	TAS
GO:0018894	Biological Process	dibenzo-p-dioxin metabolic process	IEA
GO:0048245	Biological Process	eosinophil chemotaxis	IDA
GO:0006887	Biological Process	exocytosis	IDA
GO:0007186	Biological Process	G-protein coupled receptor signaling pathway	IDA
GO:0006954	Biological Process	inflammatory response	IDA
GO:0007159	Biological Process	leukocyte cell-cell adhesion	IDA
GO:0031663	Biological Process	lipopolysaccharide-mediated signaling pathway	IDA
GO:0048247	Biological Process	lymphocyte chemotaxis	IBA
GO:0048246	Biological Process	macrophage chemotaxis	TAS
GO:0000165	Biological Process	MAPK cascade	IMP
GO:0002548	Biological Process	monocyte chemotaxis	IC
GO:0043922	Biological Process	negative regulation by host of viral transcription	IDA
GO:0070100	Biological Process	negative regulation of chemokine-mediated signaling pathway	IDA
GO:0045744	Biological Process	negative regulation of G-protein coupled receptor protein signaling pathway	IDA
GO:2000110	Biological Process	negative regulation of macrophage apoptotic process	IEA
GO:1901215	Biological Process	negative regulation of neuron death	IEA
GO:0070233	Biological Process	negative regulation of T cell apoptotic process	IDA
GO:0045071	Biological Process	negative regulation of viral genome replication	IDA
GO:0042119	Biological Process	neutrophil activation	IDA
GO:0030593	Biological Process	neutrophil chemotaxis	IBA
GO:0050918	Biological Process	positive chemotaxis	IDA
GO:0010535	Biological Process	positive regulation of activation of JAK2 kinase activity	TAS
GO:0045766	Biological Process	positive regulation of angiogenesis	IEA
GO:0051928	Biological Process	positive regulation of calcium ion transport	IDA
GO:0045785	Biological Process	positive regulation of cell adhesion	IDA
GO:0030335	Biological Process	positive regulation of cell migration	IDA
GO:0033634	Biological Process	positive regulation of cell-cell adhesion mediated by integrin	IDA
GO:0031328	Biological Process	positive regulation of cellular biosynthetic process	IDA
GO:0050679	Biological Process	positive regulation of epithelial cell proliferation	IEA
GO:0070374	Biological Process	positive regulation of ERK1 and ERK2 cascade	IBA
GO:0031622	Biological Process	positive regulation of fever generation	IEA
GO:0043547	Biological Process	positive regulation of GTPase activity	IBA
GO:0034112	Biological Process	positive regulation of homotypic cell-cell adhesion	IDA
GO:0050729	Biological Process	positive regulation of inflammatory response	IBA
GO:0045089	Biological Process	positive regulation of innate immune response	TAS
GO:0046427	Biological Process	positive regulation of JAK-STAT cascade	TAS
GO:0010759	Biological Process	positive regulation of macrophage chemotaxis	IDA
GO:0060754	Biological Process	positive regulation of mast cell chemotaxis	IEA
GO:0090026	Biological Process	positive regulation of monocyte chemotaxis	IDA
GO:2000503	Biological Process	positive regulation of natural killer cell chemotaxis	IDA
GO:0045666	Biological Process	positive regulation of neuron differentiation	IEA
GO:0045672	Biological Process	positive regulation of osteoclast differentiation	IEA
GO:0014068	Biological Process	positive regulation of phosphatidylinositol 3-kinase signaling	IDA
GO:0042327	Biological Process	positive regulation of phosphorylation	IDA
GO:0061098	Biological Process	positive regulation of protein tyrosine kinase activity	IDA
GO:0014911	Biological Process	positive regulation of smooth muscle cell migration	IDA
GO:0048661	Biological Process	positive regulation of smooth muscle cell proliferation	IDA
GO:0070234	Biological Process	positive regulation of T cell apoptotic process	IDA
GO:0010820	Biological Process	positive regulation of T cell chemotaxis	IDA
GO:2000406	Biological Process	positive regulation of T cell migration	IDA
GO:0042102	Biological Process	positive regulation of T cell proliferation	IDA
GO:0045948	Biological Process	positive regulation of translational initiation	NAS
GO:0042531	Biological Process	positive regulation of tyrosine phosphorylation of STAT protein	IDA
GO:0045070	Biological Process	positive regulation of viral genome replication	TAS
GO:0043491	Biological Process	protein kinase B signaling	IMP
GO:0051262	Biological Process	protein tetramerization	IDA
GO:0002676	Biological Process	regulation of chronic inflammatory response	TAS
GO:0050796	Biological Process	regulation of insulin secretion	IDA
GO:1901214	Biological Process	regulation of neuron death	IDA
GO:0050863	Biological Process	regulation of T cell activation	IDA
GO:0014823	Biological Process	response to activity	IEA
GO:0070723	Biological Process	response to cholesterol	IEA
GO:0042493	Biological Process	response to drug	IEA
GO:0043627	Biological Process	response to estrogen	IEA
GO:0051384	Biological Process	response to glucocorticoid	IEA
GO:0032868	Biological Process	response to insulin	IEA
GO:0009651	Biological Process	response to salt stress	IEA
GO:0009636	Biological Process	response to toxic substance	IDA
GO:0009615	Biological Process	response to virus	TAS	less<<

Modification

Modification	Residue	Position
Methionine sulfoxide	Met	65

Length

Sequence

YSSDTTPCCF AYIARPLPRA HIKEYFYTSG KCSNPAVVFV TRKNRQVCAN PEKKWVREYI NSLEMS

Properties

View

Disulfide bond

Structure

DSSP

Helix (H, G, I): 20.59%

Beta strand (B, E): 27.94%

Turn (S, T): 20.59%

Coil (C): 30.88%

1    MGYSSDTTPC  CFAYIARPMP  RAHIKEYFYT  SGKCSNPAVV  FVTRKNRQVC  ANPEKKWVRE
          B EEE   SS  SS     GGGEEEEEE    TTSSS  EE  EEETT  EEE  E TTSHHHHH
61   YINSLEMS
     HHHHHH

Pfam

Accession NO.	Identifier	Description
PF00048	IL8	Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP

Class	Fold	Superfamily	Family
Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)