Bioactive peptide information

BP0949

Name

Lymphotactin

Organism

Homo sapiens

Family

intercrine gamma family

Classification

Cytokine/Growth factor

UniProt ID

XCL1_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	TAS
GO:0005615	Cellular Component	extracellular space	ISS
GO:0005622	Cellular Component	intracellular	ISS
GO:0048020	Molecular Function	CCR chemokine receptor binding	IBA
GO:0008009	Molecular Function	chemokine activity	IDA	more>>
GO:0042379	Molecular Function	chemokine receptor binding	IDA
GO:0042803	Molecular Function	protein homodimerization activity	IDA
GO:0007267	Biological Process	cell-cell signaling	IDA
GO:0071346	Biological Process	cellular response to interferon-gamma	IBA
GO:0071347	Biological Process	cellular response to interleukin-1	IBA
GO:0071353	Biological Process	cellular response to interleukin-4	ISS
GO:0071560	Biological Process	cellular response to transforming growth factor beta stimulus	ISS
GO:0071356	Biological Process	cellular response to tumor necrosis factor	IBA
GO:0070098	Biological Process	chemokine-mediated signaling pathway	IBA
GO:0007186	Biological Process	G-protein coupled receptor signaling pathway	IBA
GO:0006954	Biological Process	inflammatory response	IBA
GO:0035782	Biological Process	mature natural killer cell chemotaxis	IDA
GO:0002548	Biological Process	monocyte chemotaxis	IBA
GO:2000562	Biological Process	negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA
GO:0032689	Biological Process	negative regulation of interferon-gamma production	IDA
GO:0032703	Biological Process	negative regulation of interleukin-2 production	IDA
GO:0043433	Biological Process	negative regulation of sequence-specific DNA binding transcription factor activity	IDA
GO:0002725	Biological Process	negative regulation of T cell cytokine production	IDA
GO:2000518	Biological Process	negative regulation of T-helper 1 cell activation	IDA
GO:0002826	Biological Process	negative regulation of T-helper 1 type immune response	IC
GO:0045892	Biological Process	negative regulation of transcription, DNA-templated	IDA
GO:0030593	Biological Process	neutrophil chemotaxis	TAS
GO:2000538	Biological Process	positive regulation of B cell chemotaxis	ISS
GO:2000563	Biological Process	positive regulation of CD4-positive, alpha-beta T cell proliferation	ISS
GO:2000566	Biological Process	positive regulation of CD8-positive, alpha-beta T cell proliferation	IDA
GO:0070374	Biological Process	positive regulation of ERK1 and ERK2 cascade	IBA
GO:2000513	Biological Process	positive regulation of granzyme A production	IDA
GO:0071663	Biological Process	positive regulation of granzyme B production	IDA
GO:0043547	Biological Process	positive regulation of GTPase activity	IBA
GO:2000558	Biological Process	positive regulation of immunoglobulin production in mucosal tissue	ISS
GO:0050729	Biological Process	positive regulation of inflammatory response	IBA
GO:0032733	Biological Process	positive regulation of interleukin-10 production	IDA
GO:0002690	Biological Process	positive regulation of leukocyte chemotaxis	ISS
GO:2000503	Biological Process	positive regulation of natural killer cell chemotaxis	IDA
GO:0090023	Biological Process	positive regulation of neutrophil chemotaxis	ISS
GO:0051281	Biological Process	positive regulation of release of sequestered calcium ion into cytosol	IDA
GO:0010820	Biological Process	positive regulation of T cell chemotaxis	IDA
GO:0002726	Biological Process	positive regulation of T cell cytokine production	ISS
GO:0001916	Biological Process	positive regulation of T cell mediated cytotoxicity	IDA
GO:2000556	Biological Process	positive regulation of T-helper 1 cell cytokine production	ISS
GO:2000553	Biological Process	positive regulation of T-helper 2 cell cytokine production	ISS
GO:2000412	Biological Process	positive regulation of thymocyte migration	ISS
GO:0071636	Biological Process	positive regulation of transforming growth factor beta production	IDA
GO:0050727	Biological Process	regulation of inflammatory response	IDA
GO:0051209	Biological Process	release of sequestered calcium ion into cytosol	ISS
GO:0009615	Biological Process	response to virus	IDA
GO:0007165	Biological Process	signal transduction	IC	less<<

Modification

Length

Sequence

VGSEVSDKRT CVSLTTQRLP VSRIKTYTIT EGSLRAVIFI TKRGLKVCAD PQATWVRDVV RSMDRKSNTR
NNMIQTKPTG TQQSTNTAVT LTG

Properties

View

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
1J8I	NMR	-	A	1-93
1J9O	NMR	-	A	1-93
2HDM	NMR	-	A	2-93
2JP1	NMR	-	A/B	1-93
2N54	NMR	-	A/B	1-93
2NYZ	X-ray	2.60 A	D/E	1-93
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 17.20%

Beta strand (B, E): 16.13%

Turn (S, T): 22.58%

Coil (C): 44.09%

1    VGSEVSDKRT  CVSLTTQRLP  VSRIKTYTIT  EGSLRAVIFI  TKRGLKVCAD  PQATWVRDVV
        S SS SS   SSS        GGGEEEEEE    STT  EEEE  ETTS EEEE   TT HHHHHHH
61   RSMDRKSNTR  NNMIQTKPTG  TQQSTNTAVT  LTG
     HHHHHHTTTT  S

Pfam

Accession NO.	Identifier	Description
PF00048	IL8	Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP

Class	Fold	Superfamily	Family
Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)