Bioactive peptide information

BP0906

Name

Growth/differentiation factor 5

Organism

Homo sapiens

Family

TGF-beta family

Classification

Cytokine/Growth factor

UniProt ID

GDF5_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	TAS
GO:0005615	Cellular Component	extracellular space	IBA
GO:0005622	Cellular Component	intracellular	IDA
GO:0005886	Cellular Component	plasma membrane	IEA
GO:0036122	Molecular Function	BMP binding	IPI	more>>
GO:0005125	Molecular Function	cytokine activity	IBA
GO:0008083	Molecular Function	growth factor activity	TAS
GO:0042802	Molecular Function	identical protein binding	IPI
GO:0005160	Molecular Function	transforming growth factor beta receptor binding	IBA
GO:0030509	Biological Process	BMP signaling pathway	IBA
GO:0048468	Biological Process	cell development	IBA
GO:0007267	Biological Process	cell-cell signaling	TAS
GO:0060591	Biological Process	chondroblast differentiation	IDA
GO:0002062	Biological Process	chondrocyte differentiation	IEA
GO:0030326	Biological Process	embryonic limb morphogenesis	IEA
GO:0030198	Biological Process	extracellular matrix organization	TAS
GO:0035136	Biological Process	forelimb morphogenesis	IEA
GO:0040007	Biological Process	growth	IEA
GO:0035137	Biological Process	hindlimb morphogenesis	IEA
GO:0098779	Biological Process	mitophagy in response to mitochondrial depolarization	IGI
GO:0032331	Biological Process	negative regulation of chondrocyte differentiation	IDA
GO:0050680	Biological Process	negative regulation of epithelial cell proliferation	IDA
GO:2001054	Biological Process	negative regulation of mesenchymal cell apoptotic process	IEA
GO:0043524	Biological Process	negative regulation of neuron apoptotic process	IEA
GO:0030513	Biological Process	positive regulation of BMP signaling pathway	IDA
GO:0032332	Biological Process	positive regulation of chondrocyte differentiation	IDA
GO:0045666	Biological Process	positive regulation of neuron differentiation	IEA
GO:0010862	Biological Process	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA
GO:0042981	Biological Process	regulation of apoptotic process	IBA
GO:0043408	Biological Process	regulation of MAPK cascade	IBA
GO:0040014	Biological Process	regulation of multicellular organism growth	IEA
GO:0007184	Biological Process	SMAD protein import into nucleus	IDA
GO:0060395	Biological Process	SMAD protein signal transduction	IDA
GO:0007179	Biological Process	transforming growth factor beta receptor signaling pathway	TAS	less<<

Modification

Length

120

Sequence

APLATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT
LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR

Properties

View

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
2BHK	X-ray	2.40 A	A	1-120
1WAQ	X-ray	2.28 A	A	6-120
3EVS	X-ray	2.10 A	B	6-120
3QB4	X-ray	2.28 A	A/C	6-120
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 15.00%

Beta strand (B, E): 39.17%

Turn (S, T): 13.33%

Coil (C): 32.50%

1    APLATRQGKR  PSKNLKARCS  RKALHVNFKD  MGWDDWIIAP  LEYEAFHCEG  LCEFPLRSHL
                        BSE  EE  EEEGGG  SS TTTEEE   SEEE  EEE   B  SS  GGG
61   EPTNHAVIQT  LMNSMDPEST  PPTCCVPTRL  SPISILFIDS  ANNVVYKQYE  DMVVESCGCR
        HHHHHHH  HHHHH TTTS      EEEEEE  EEEEEEEE T  TS EEEEEEE  EEEEEEEEE
121

Pfam

Accession NO.	Identifier	Description
PF00019	TGF_beta	Transforming growth factor beta like domain

SCOP

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines