Bioactive peptide information

BP0903

Name

Artemin

Organism

Homo sapiens

Family

TGF-beta family

Classification

Cytokine/Growth factor

UniProt ID

ARTN_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005615	Cellular Component	extracellular space	IEA
GO:0005102	Molecular Function	receptor binding	TAS
GO:0007411	Biological Process	axon guidance	TAS
GO:0050930	Biological Process	induction of positive chemotaxis	IEA
GO:0097021	Biological Process	lymphocyte migration into lymphoid organs	IEA	more>>
GO:0007405	Biological Process	neuroblast proliferation	TAS
GO:0007422	Biological Process	peripheral nervous system development	IEA
GO:0061146	Biological Process	Peyer's patch morphogenesis	IEA
GO:0007165	Biological Process	signal transduction	TAS	less<<

Modification

Length

113

Sequence

AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGSCRRA RSPHDLSLAS LLGAGALRPP
PGSRPVSQPC CRPTRYEAVS FMDVNSTWRT VDRLSATACG CLG

Properties

View

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
2ASK	X-ray	1.55 A	A/B	1-113
2GH0	X-ray	1.92 A	C/D	15-113
2GYR	X-ray	2.60 A	A/B/C/D/E/F	15-113
2GYZ	X-ray	1.76 A	A	15-113
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 16.81%

Beta strand (B, E): 40.71%

Turn (S, T): 12.39%

Coil (C): 30.09%

1    AGGPGSRARA  AGARGCRLRS  QLVPVRALGL  GHRSDELVRF  RFCSGSCRRA  RSPHDLSLAS
                     BSEEEE  EEEEGGGGSS  S     EEEE  EEEE B GGG    HHHHHHHH
61   LLGAGALRPP  PGSRPVSQPC  CRPTRYEAVS  FMDVNSTWRT  VDRLSATACG  CLG
     HHHHT S     SSS   SS E  EEEEEEEEEE  EE TTS EEE  EEEEEEEEEE  EE

Pfam

Accession NO.	Identifier	Description
PF00019	TGF_beta	Transforming growth factor beta like domain

SCOP

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines