Bioactive peptide information

Bioactive peptide information

ID

BP0873

Name

Atrial natriuretic factor

Organism

Homo sapiens

Family

natriuretic peptide family

Classification

Hormone

UniProt ID

GO

GO ID	GO Term	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	NAS
GO:0005615	Cellular Component	extracellular space	IEA
GO:0042629	Cellular Component	mast cell granule	IEA
GO:0005634	Cellular Component	nucleus	IEA
GO:0048471	Cellular Component	perinuclear region of cytoplasm	IEA	more>>
GO:0005184	Molecular Function	neuropeptide hormone activity	IMP
GO:0071855	Molecular Function	neuropeptide receptor binding	IMP
GO:0005102	Molecular Function	receptor binding	IDA
GO:0061337	Biological Process	cardiac conduction	TAS
GO:0014898	Biological Process	cardiac muscle hypertrophy in response to stress	IEA
GO:0061049	Biological Process	cell growth involved in cardiac muscle cell development	IEA
GO:0044267	Biological Process	cellular protein metabolic process	TAS
GO:0071260	Biological Process	cellular response to mechanical stimulus	IEA
GO:0006182	Biological Process	cGMP biosynthetic process	IDA
GO:0007565	Biological Process	female pregnancy	ISS
GO:0010467	Biological Process	gene expression	TAS
GO:0030308	Biological Process	negative regulation of cell growth	IEA
GO:1903815	Biological Process	negative regulation of collecting lymphatic vessel constriction	IEA
GO:0003085	Biological Process	negative regulation of systemic arterial blood pressure	IEA
GO:0007218	Biological Process	neuropeptide signaling pathway	IDA
GO:0060452	Biological Process	positive regulation of cardiac muscle contraction	IMP
GO:1902261	Biological Process	positive regulation of delayed rectifier potassium channel activity	IDA
GO:0010460	Biological Process	positive regulation of heart rate	IMP
GO:1903766	Biological Process	positive regulation of potassium ion export across plasma membrane	IDA
GO:0007168	Biological Process	receptor guanylyl cyclase signaling pathway	IDA
GO:0060372	Biological Process	regulation of atrial cardiac muscle cell membrane repolarization	IMP
GO:0008217	Biological Process	regulation of blood pressure	IDA
GO:0050880	Biological Process	regulation of blood vessel size	IEA
GO:1903779	Biological Process	regulation of cardiac conduction	TAS
GO:1902514	Biological Process	regulation of generation of L-type calcium current	ISS
GO:1901841	Biological Process	regulation of high voltage-gated calcium channel activity	ISS
GO:0001666	Biological Process	response to hypoxia	IEA
GO:0032868	Biological Process	response to insulin	IEA
GO:0035994	Biological Process	response to muscle stretch	TAS
GO:0006367	Biological Process	transcription initiation from RNA polymerase II promoter	TAS	less<<

Modification

NA

Length

28

Sequence

SLRRSSCFGG RMDRIGAQSG LGCNSFRY

Properties

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
1ANP	NMR	-	A	1-28
1YK0	X-ray	2.40 A	E	6-26
3N57	X-ray	3.03 A	C/D	1-28
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 0.00%

Beta strand (B, E): 0.00%

Turn (S, T): 0.00%

Coil (C): 100.00%

1 SLDRSSCFTG SLDSIRAQSG LGCNSFRY

Pfam

NA

SCOP

Class	Fold	Superfamily	Family
Peptides	Atrial natriuretic peptide	Atrial natriuretic peptide	Atrial natriuretic peptide

CATH

NA