Bioactive peptide information

BP0866

Name

Leukemia inhibitory factor

Organism

Homo sapiens

Family

LIF/OSM family

Classification

Cytokine/Growth factor

UniProt ID

LIF_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005737	Cellular Component	cytoplasm	IDA
GO:0005576	Cellular Component	extracellular region	TAS
GO:0005615	Cellular Component	extracellular space	IC
GO:0005125	Molecular Function	cytokine activity	IDA
GO:0008083	Molecular Function	growth factor activity	IDA	more>>
GO:0005146	Molecular Function	leukemia inhibitory factor receptor binding	IPI
GO:0005102	Molecular Function	receptor binding	IPI
GO:0001135	Molecular Function	transcription factor activity, RNA polymerase II transcription factor recruiting	IDA
GO:0048708	Biological Process	astrocyte differentiation	IEA
GO:0001974	Biological Process	blood vessel remodeling	IEA
GO:0046697	Biological Process	decidualization	IEA
GO:0007566	Biological Process	embryo implantation	IEA
GO:0006955	Biological Process	immune response	IEA
GO:0048861	Biological Process	leukemia inhibitory factor signaling pathway	IDA
GO:0048286	Biological Process	lung alveolus development	IEA
GO:0060463	Biological Process	lung lobe morphogenesis	IEA
GO:0060426	Biological Process	lung vasculature development	IEA
GO:0007275	Biological Process	multicellular organism development	TAS
GO:0048644	Biological Process	muscle organ morphogenesis	IEA
GO:0016525	Biological Process	negative regulation of angiogenesis	IEA
GO:0008285	Biological Process	negative regulation of cell proliferation	IEA
GO:0070373	Biological Process	negative regulation of ERK1 and ERK2 cascade	IEA
GO:0046888	Biological Process	negative regulation of hormone secretion	IDA
GO:0045835	Biological Process	negative regulation of meiotic nuclear division	IEA
GO:0048666	Biological Process	neuron development	IEA
GO:0031100	Biological Process	organ regeneration	IEA
GO:0048711	Biological Process	positive regulation of astrocyte differentiation	IEA
GO:0008284	Biological Process	positive regulation of cell proliferation	IDA
GO:0051461	Biological Process	positive regulation of corticotropin secretion	IEA
GO:1901676	Biological Process	positive regulation of histone H3-K27 acetylation	IDA
GO:0045651	Biological Process	positive regulation of macrophage differentiation	IDA
GO:0043410	Biological Process	positive regulation of MAPK cascade	IDA
GO:0072108	Biological Process	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IDA
GO:0010976	Biological Process	positive regulation of neuron projection development	IEA
GO:0033138	Biological Process	positive regulation of peptidyl-serine phosphorylation	IDA
GO:0033141	Biological Process	positive regulation of peptidyl-serine phosphorylation of STAT protein	IDA
GO:0050731	Biological Process	positive regulation of peptidyl-tyrosine phosphorylation	IDA
GO:1900182	Biological Process	positive regulation of protein localization to nucleus	IDA
GO:0045944	Biological Process	positive regulation of transcription from RNA polymerase II promoter	IDA
GO:0042511	Biological Process	positive regulation of tyrosine phosphorylation of Stat1 protein	IDA
GO:0042517	Biological Process	positive regulation of tyrosine phosphorylation of Stat3 protein	IDA
GO:0072307	Biological Process	regulation of metanephric nephron tubule epithelial cell differentiation	IDA
GO:1903025	Biological Process	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	IEA
GO:0060041	Biological Process	retina development in camera-type eye	IEA
GO:0060708	Biological Process	spongiotrophoblast differentiation	IEA
GO:0048863	Biological Process	stem cell differentiation	IEA
GO:0019827	Biological Process	stem cell population maintenance	IEA
GO:0060290	Biological Process	transdifferentiation	IEA
GO:0060707	Biological Process	trophoblast giant cell differentiation	IEA
GO:0042503	Biological Process	tyrosine phosphorylation of Stat3 protein	IEA	less<<

Modification

Length

180

Sequence

SPLPITPVNA  TCAIRHPCHN  NLMNQIRSQL  AQLNGSANAL  FILYYTAQGE  PFPNNLDKLC  GPNVTDFPPF
HANGTEKAKL  VELYRIVVYL  GTSLGNITRD  QKILNPSALS  LHSKLNATAD  ILRGLLSNVL  CRLCSKYHVG
HVDVTYGPDT  SGKDVFQKKK  LGCQLLGKYK  QIIAVLAQAF

Properties

View

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
1EMR	X-ray	3.50 A	A	22-180
1PVH	X-ray	2.50 A	B/D	12-180
2Q7N	X-ray	4.00 A	B/D	1-180
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 59.44%

Beta strand (B, E): 0.00%

Turn (S, T): 18.33%

Coil (C): 22.22%

1    SPLPITPVNA  TCAIRHPCHN  NLMNQIRSQL  AQLNGSANAL  FILYYTAQGE  PFPNNLDKLC
            SS    SSSS    S   THHHHHHHH  HHHHHHHHHH  HHHHHHHT T  TTTTSHHHHS
61   GPNVTDFPPF  HANGTEKAKL  VELYRIVVYL  GTSLGNITRD  QKILNPSALS  LHSKLNATAD
      TT SS       SSS HHHHH  HHHHHHHHHH  HHHHHHHHHH  HHHH  S HH  HHHHHHHHHH
121  ILRGLLSNVL  CRLCSKYHVG  HVDVTYGPDT  SGKDVFQKKK  LGCQLLGKYK  QIIAVLAQAF
     HHHHHHHHHH  HHTTTTT     S      S S     SHHHHHH  HHHHHHHHHH  HHHHHHHHH
181

Pfam

Accession NO.	Identifier	Description
PF01291	LIF_OSM	LIF / OSM family

SCOP

Class	Fold	Superfamily	Family
All alpha proteins	4-helical cytokines	4-helical cytokines	Long-chain cytokines

CATH

Class	Architecture	Topology	Homology
Mainly Alpha	Up-down Bundle	Growth Hormone; Chain: A;