Bioactive peptide information

BP0808

Name

Fibroblast growth factor 7

Organism

Rattus norvegicus

Family

heparin-binding growth factors family

Classification

Cytokine/Growth factor

UniProt ID

FGF7_RAT

GO ID	GO Term	Definition	Evidence
GO:0005615	Cellular Component	extracellular space	IDA
GO:0008083	Molecular Function	growth factor activity	IMP
GO:0008201	Molecular Function	heparin binding	IDA
GO:0005111	Molecular Function	type 2 fibroblast growth factor receptor binding	IDA
GO:0008543	Biological Process	fibroblast growth factor receptor signaling pathway	IEA	more>>
GO:0030324	Biological Process	lung development	IMP
GO:0001541	Biological Process	ovarian follicle development	IMP
GO:0006656	Biological Process	phosphatidylcholine biosynthetic process	IMP
GO:0008654	Biological Process	phospholipid biosynthetic process	IMP
GO:0051781	Biological Process	positive regulation of cell division	IEA
GO:0050679	Biological Process	positive regulation of epithelial cell proliferation	IDA
GO:0043129	Biological Process	surfactant homeostasis	IMP
GO:0042060	Biological Process	wound healing	IDA	less<<

Modification

Length

163

Sequence

CNDMSPEQTA  TSVNCSSPER  HTRSYDYMEG  GDIRVRRLFC  RTQWYLRIDK  RGKVKGTQEM  RNSYNIMEIM
TVAVGIVAIK  GVESEYYLAM  NKQGELYAKK  ECNEDCNFKE  LILENHYNTS  ASAKWTHSGG  EMFVALNQKG
LPVKGKKTKK  EQKTAHFLPM  AIT

Properties

View

Structure

PDB	Method	Resolution	Chain	Position
1QQK	X-ray	3.10 A	A/B	24-163
1QQL	X-ray	2.30 A	A	24-99
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 2.14%

Beta strand (B, E): 33.57%

Turn (S, T): 27.14%

Coil (C): 37.14%

1    SYDYMEGGDI  RVRRLFCRTQ  WYLRIDKRGK  VKGTQEMRNS  YNIMEIRTVA  VGIVAIKGVE
              E  EEEEEEETTS   EEEE TTS   EEEES TT S  TTEEEEEE S  SSEEEEEETT
61   SEYYLAMNKE  GKLYAKKECN  EDCNFKELIL  ENHYNTYASA  KWTHSGGEMF  VALNQKGLPV
     T    EE TT    EE  SS    STT EE  EE  TTTEE  EES           B    B TTS B
121  KGKKTKKEQK  TAHFLPMAIT
      GGG  TTSS  TT EEEE

Pfam

Accession NO.	Identifier	Description
PF00167	FGF	Fibroblast growth factor

SCOP

Class	Fold	Superfamily	Family
All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)