Bioactive peptide information

BP0750

Name

Omega-conotoxin GVIA

Organism

Conus geographus

Family

conotoxin O1 superfamily

Classification

Toxin and venom peptide

UniProt ID

GO ID	GO Term	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	IEA
GO:0072556	Cellular Component	other organism presynaptic membrane	IEA
GO:0008200	Molecular Function	ion channel inhibitor activity	IEA
GO:0009405	Biological Process	pathogenesis	IEA

Modification

Modification	Residue	Position
4-hydroxyproline	Pro	4
4-hydroxyproline	Pro	10
4-hydroxyproline	Pro	21
Tyrosine amide; in form omega-conotoxinGVIA	Tyr	27

Length

Sequence

CKSPGSSCSP TSYNCCRSCN PYTKRCY

Properties

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
1OMC	NMR	-	A	1-27
1TR6	NMR	-	A	1-27
1TTL	NMR	-	A	1-27
2CCO	NMR	-	A	1-27
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DSSP

Helix (H, G, I): 0.00%

Beta strand (B, E): 25.00%

Turn (S, T): 42.86%

Coil (C): 32.14%

1 CKSPGSSCSP TSYNCCRSCN PYTKRCYX
B TT B T TTT BSS EE TTTTEE

Pfam

SCOP

Class	Fold	Superfamily	Family
Small proteins	Knottins (small inhibitors, toxins, lectins)	omega toxin-like	Conotoxin

CATH

Cystine knot