Bioactive peptide information

BP0698

Name

C-C motif chemokine 7

Organism

Homo sapiens

Family

intercrine beta (chemokine CC) family

Classification

Cytokine/Growth factor

UniProt ID

CCL7_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005623	Cellular Component	cell	TAS
GO:0005576	Cellular Component	extracellular region	TAS
GO:0005615	Cellular Component	extracellular space	TAS
GO:0031726	Molecular Function	CCR1 chemokine receptor binding	IPI
GO:0008009	Molecular Function	chemokine activity	IDA	more>>
GO:0008201	Molecular Function	heparin binding	IEA
GO:0007267	Biological Process	cell-cell signaling	TAS
GO:0006874	Biological Process	cellular calcium ion homeostasis	TAS
GO:0071361	Biological Process	cellular response to ethanol	IEA
GO:0071346	Biological Process	cellular response to interferon-gamma	IBA
GO:0071347	Biological Process	cellular response to interleukin-1	IBA
GO:0071356	Biological Process	cellular response to tumor necrosis factor	IBA
GO:0070098	Biological Process	chemokine-mediated signaling pathway	IBA
GO:0006935	Biological Process	chemotaxis	TAS
GO:0007010	Biological Process	cytoskeleton organization	IDA
GO:0048245	Biological Process	eosinophil chemotaxis	IDA
GO:0007186	Biological Process	G-protein coupled receptor signaling pathway	IBA
GO:0006954	Biological Process	inflammatory response	IBA
GO:0048247	Biological Process	lymphocyte chemotaxis	IBA
GO:0002548	Biological Process	monocyte chemotaxis	IC
GO:0030593	Biological Process	neutrophil chemotaxis	IBA
GO:0030335	Biological Process	positive regulation of cell migration	IDA
GO:0070374	Biological Process	positive regulation of ERK1 and ERK2 cascade	IBA
GO:0043547	Biological Process	positive regulation of GTPase activity	IBA
GO:0050729	Biological Process	positive regulation of inflammatory response	IBA
GO:2000503	Biological Process	positive regulation of natural killer cell chemotaxis	IDA
GO:0008360	Biological Process	regulation of cell shape	IDA
GO:0010332	Biological Process	response to gamma radiation	IEA
GO:0007165	Biological Process	signal transduction	TAS	less<<

Modification

Modification	Residue	Position
Pyrrolidone carboxylic acid	Gln	1

Length

Sequence

QPVGINTSTT CCYRFINKKI PKQRLESYRR TTSSHCPREA VIFKTKLDKE ICADPTQKWV QDFMKHLDKK
TQTPKL

Properties

View

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
1BO0	NMR	-	A	1-76
1NCV	NMR	-	A/B	1-76
4ZKC	X-ray	3.15 A	B	1-76
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 14.47%

Beta strand (B, E): 19.74%

Turn (S, T): 27.63%

Coil (C): 38.16%

1    QPVGINTSTT  CCYRFINKKI  PKQRLESYRR  TTSSHCPREA  VIFKTKLDKE  ICADPTQKWV
       SS  SS           S     TTTEEEEEE    TTT SS    EEEEETTS E  EEE TTSHHH
61   QDFMKHLDKK  TQTPKL
     HHHHHHHH S   S

Pfam

Accession NO.	Identifier	Description
PF00048	IL8	Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP

Class	Fold	Superfamily	Family
Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)