Bioactive peptide information

BP0696

Name

C-C motif chemokine 1

Organism

Homo sapiens

Family

intercrine beta (chemokine CC) family

Classification

Cytokine/Growth factor

UniProt ID

CCL1_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005623	Cellular Component	cell	TAS
GO:0005615	Cellular Component	extracellular space	TAS
GO:0048020	Molecular Function	CCR chemokine receptor binding	IBA
GO:0008009	Molecular Function	chemokine activity	TAS
GO:0006874	Biological Process	cellular calcium ion homeostasis	TAS	more>>
GO:0071346	Biological Process	cellular response to interferon-gamma	IBA
GO:0071347	Biological Process	cellular response to interleukin-1	IBA
GO:0071356	Biological Process	cellular response to tumor necrosis factor	IBA
GO:0070098	Biological Process	chemokine-mediated signaling pathway	IBA
GO:0006935	Biological Process	chemotaxis	TAS
GO:0007186	Biological Process	G-protein coupled receptor signaling pathway	IBA
GO:0006954	Biological Process	inflammatory response	IBA
GO:0048247	Biological Process	lymphocyte chemotaxis	IBA
GO:0002548	Biological Process	monocyte chemotaxis	IBA
GO:0030593	Biological Process	neutrophil chemotaxis	IBA
GO:0070374	Biological Process	positive regulation of ERK1 and ERK2 cascade	IBA
GO:0043547	Biological Process	positive regulation of GTPase activity	IBA
GO:0050729	Biological Process	positive regulation of inflammatory response	IBA
GO:0051384	Biological Process	response to glucocorticoid	IEA
GO:0007165	Biological Process	signal transduction	TAS
GO:0016032	Biological Process	viral process	TAS	less<<

Modification

Length

Sequence

KSMQVPFSRC CFSFAEQEIP LRAILCYRNT SSICSNEGLI FKLKRGKEAC ALDTVGWVQR HRKMLRHCPS
KRK

Properties

View

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
1EL0	NMR	-	A	1-73
4OIJ	X-ray	2.00 A	A/B	1-73
4OIK	X-ray	2.10 A	A/B	1-73
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 14.86%

Beta strand (B, E): 21.62%

Turn (S, T): 31.08%

Coil (C): 32.43%

1    SKSMQVPFSR  CCFSFAEQEI  PLRAILCYRN  TSSICSNEGL  IFKLKRGKEA  CALDTVGWVQ
        S SSS      SS S S     TTTEEEEEE    GGGSS  E  EEEESSSSEE  EE S SSHHH
61   RHRKMLRHCP  SKRK
     HHHHHS B    SS

Pfam

Accession NO.	Identifier	Description
PF00048	IL8	Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP

Class	Fold	Superfamily	Family
Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)