Bioactive peptide information

BP0207

Name

Interleukin-3

Organism

Mus musculus

Family

IL-3 family

Classification

Cytokine/Growth factor

UniProt ID

IL3_MOUSE

GO ID	GO Term	Definition	Evidence
GO:0005615	Cellular Component	extracellular space	IDA
GO:0005125	Molecular Function	cytokine activity	IDA
GO:0008083	Molecular Function	growth factor activity	IDA
GO:0005135	Molecular Function	interleukin-3 receptor binding	IPI
GO:0042976	Biological Process	activation of Janus kinase activity	IDA	more>>
GO:0019221	Biological Process	cytokine-mediated signaling pathway	IDA
GO:0097192	Biological Process	extrinsic apoptotic signaling pathway in absence of ligand	IDA
GO:0006955	Biological Process	immune response	IEA
GO:0038156	Biological Process	interleukin-3-mediated signaling pathway	IDA
GO:0030224	Biological Process	monocyte differentiation	IGI
GO:0033028	Biological Process	myeloid cell apoptotic process	IDA
GO:0043066	Biological Process	negative regulation of apoptotic process	IDA
GO:0010507	Biological Process	negative regulation of autophagy	IDA
GO:0033026	Biological Process	negative regulation of mast cell apoptotic process	IDA
GO:0008284	Biological Process	positive regulation of cell proliferation	IDA
GO:0046330	Biological Process	positive regulation of JNK cascade	IDA
GO:0070668	Biological Process	positive regulation of mast cell proliferation	IDA
GO:0002763	Biological Process	positive regulation of myeloid leukocyte differentiation	IGI
GO:0050731	Biological Process	positive regulation of peptidyl-tyrosine phosphorylation	IDA
GO:0001934	Biological Process	positive regulation of protein phosphorylation	IDA
GO:0001558	Biological Process	regulation of cell growth	IGI
GO:0010468	Biological Process	regulation of gene expression	IDA
GO:0006110	Biological Process	regulation of glycolytic process	IGI
GO:0035304	Biological Process	regulation of protein dephosphorylation	IDA
GO:0001666	Biological Process	response to hypoxia	IGI	less<<

Modification

Length

140

Sequence

ASISGRDTHR LTRTLNCSSI VKEIIGKLPE PELKTDDEGP SLRNKSFRRV NLSKFVESQG EVDPEDRYVI
KSNLQKLNCC LPTSANDSAL PGVFIRDLDD FRKKLRFYMV HLNDLETVLT SRPPQPASGS VSPNRGTVEC

Properties

View

Disulfide bond

Structure

DSSP

Helix (H, G, I): 41.73%

Beta strand (B, E): 0.00%

Turn (S, T): 24.41%

Coil (C): 33.86%

1    GAMDTHRLTR  TLNCSSIVKE  IIGKLPEPEL  KTDDEGPSLR  NKSFRRVNLS  KFVESQGEVD
          S SSS  SS  HHHHHH  HHHHS    S  S   S SGGG   TTTHHHHHH  HHHHHHTTT
61   PEDRYVIKSN  LQKLNACLPT  SANDSALPGV  FIRDLDDFRK  KLRFYMVHLN  DLETVLTSRP
     GGGGS  HHH  HHHHHHHS       SS         S HHHHHH  HHHHHHHHT   SSS SS
121  PQPASGS
      SSS

Pfam

Accession NO.	Identifier	Description
PF02059	IL3	Interleukin-3

SCOP

CATH