Bioactive peptide information

BP0187

Name

Fibroblast growth factor 4

Organism

Homo sapiens

Family

heparin-binding growth factors family

Classification

Cytokine/Growth factor

UniProt ID

FGF4_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	TAS
GO:0005622	Cellular Component	intracellular	TAS
GO:0008083	Molecular Function	growth factor activity	TAS
GO:0008201	Molecular Function	heparin binding	IEA
GO:0000186	Biological Process	activation of MAPKK activity	TAS	more>>
GO:0060561	Biological Process	apoptotic process involved in morphogenesis	IEA
GO:0007411	Biological Process	axon guidance	TAS
GO:0001502	Biological Process	cartilage condensation	IEA
GO:0007267	Biological Process	cell-cell signaling	TAS
GO:0060591	Biological Process	chondroblast differentiation	IDA
GO:0060363	Biological Process	cranial suture morphogenesis	IEA
GO:0035116	Biological Process	embryonic hindlimb morphogenesis	IEA
GO:0007173	Biological Process	epidermal growth factor receptor signaling pathway	TAS
GO:0038095	Biological Process	Fc-epsilon receptor signaling pathway	TAS
GO:0008543	Biological Process	fibroblast growth factor receptor signaling pathway	IGI
GO:0045087	Biological Process	innate immune response	TAS
GO:0008286	Biological Process	insulin receptor signaling pathway	TAS
GO:0000165	Biological Process	MAPK cascade	TAS
GO:0010463	Biological Process	mesenchymal cell proliferation	IDA
GO:0043066	Biological Process	negative regulation of apoptotic process	IEA
GO:0048011	Biological Process	neurotrophin TRK receptor signaling pathway	TAS
GO:0042475	Biological Process	odontogenesis of dentin-containing tooth	IEA
GO:0048015	Biological Process	phosphatidylinositol-mediated signaling	TAS
GO:0051781	Biological Process	positive regulation of cell division	IEA
GO:0008284	Biological Process	positive regulation of cell proliferation	IGI
GO:0070374	Biological Process	positive regulation of ERK1 and ERK2 cascade	IDA
GO:0045944	Biological Process	positive regulation of transcription from RNA polymerase II promoter	IEA
GO:0007265	Biological Process	Ras protein signal transduction	TAS
GO:2000544	Biological Process	regulation of endothelial cell chemotaxis to fibroblast growth factor	IDA
GO:0007165	Biological Process	signal transduction	TAS
GO:0007264	Biological Process	small GTPase mediated signal transduction	TAS
GO:0019827	Biological Process	stem cell population maintenance	IEA
GO:0048010	Biological Process	vascular endothelial growth factor receptor signaling pathway	TAS	less<<

Modification

Length

176

Sequence

APTAPNGTLE  AELERRWESL  VALSLARLPV  AAQPKEAAVQ  SGAGDYLLGI  KRLRRLYCNV  GIGFHLQALP
DGRIGGAHAD  TRDSLLELSP  VERGVVSIFG  VASRFFVAMS  SKGKLYGSPF  FTDECTFKEI  LLPNNYNAYE
SYKYPGMFIA  LSKNGKTKKG  NRVSPTMKVT  HFLPRL

Properties

View

Structure

DSSP

Helix (H, G, I): 9.38%

Beta strand (B, E): 43.75%

Turn (S, T): 25.78%

Coil (C): 21.09%

1    GIKRLRRLYC  NVGIGFHLQA  LPDGRIGGAH  ADTRDSLLEL  SPVERGVVSI  FGVASRFFVA
        EEEEEEE   STT EEEEE   TTS EEEES  S  GGG EEE  EEEETTEEEE  EETTTTEEEE
61   MSSKGKLYGS  PFFTDECTFK  EILLPNNYNA  YESYKYPGMF  IALGKNGKTK  KGNRVSPTMK
     E TT  EEEE  SS  TTSEEE  EEE GGG EE  EEESSSTT B    B TTSSB    GGG  TTSG
121  VTHFLPRL
     GG EEEE

Pfam

Accession NO.	Identifier	Description
PF00167	FGF	Fibroblast growth factor

SCOP

Class	Fold	Superfamily	Family
All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)