Bioactive peptide information

BP0168

Name

C-C motif chemokine 15

Organism

Homo sapiens

Family

intercrine beta (chemokine CC) family

Classification

Cytokine/Growth factor

UniProt ID

CCL15_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005623	Cellular Component	cell	TAS
GO:0005615	Cellular Component	extracellular space	TAS
GO:0048020	Molecular Function	CCR chemokine receptor binding	IBA
GO:0042056	Molecular Function	chemoattractant activity	IDA
GO:0008009	Molecular Function	chemokine activity	TAS	more>>
GO:0008201	Molecular Function	heparin binding	IEA
GO:0005102	Molecular Function	receptor binding	TAS
GO:0007267	Biological Process	cell-cell signaling	TAS
GO:0006874	Biological Process	cellular calcium ion homeostasis	TAS
GO:0071346	Biological Process	cellular response to interferon-gamma	IBA
GO:0071347	Biological Process	cellular response to interleukin-1	IBA
GO:0071356	Biological Process	cellular response to tumor necrosis factor	IBA
GO:0070098	Biological Process	chemokine-mediated signaling pathway	IBA
GO:0006935	Biological Process	chemotaxis	TAS
GO:0007186	Biological Process	G-protein coupled receptor signaling pathway	IBA
GO:0006954	Biological Process	inflammatory response	IBA
GO:0048247	Biological Process	lymphocyte chemotaxis	IBA
GO:0002548	Biological Process	monocyte chemotaxis	IBA
GO:0030593	Biological Process	neutrophil chemotaxis	IBA
GO:0050918	Biological Process	positive chemotaxis	IDA
GO:0070374	Biological Process	positive regulation of ERK1 and ERK2 cascade	IBA
GO:0043547	Biological Process	positive regulation of GTPase activity	IBA
GO:0050729	Biological Process	positive regulation of inflammatory response	IBA
GO:0007165	Biological Process	signal transduction	TAS	less<<

Modification

Length

Sequence

SFHFAADCCT SYISQSIPCS LMKSYFETSS ECSKPGVIFL TKKGRQVCAK PSGPGVQDCM KKLKPYSI

Properties

View

Disulfide bond

Structure

DSSP

Helix (H, G, I): 15.15%

Beta strand (B, E): 24.24%

Turn (S, T): 28.79%

Coil (C): 31.82%

1    HFAADCCTSY  ISQSIPCSLM  KSYFETSSEC  SKPGVIFLTK  KGRQVCAKPS  GPGVQDCMKK
            SS    SSS  GGGE  EEEEE  TTS  SS  EEEEET  TTEEEEE SS   TTHHHHHHH
61   LKPYSI
     TS

Pfam

Accession NO.	Identifier	Description
PF00048	IL8	Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP

Class	Fold	Superfamily	Family
Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)