Bioactive peptide information

BP0009

Name

Insulin B chain

Organism

Bos taurus

Family

insulin family

Classification

Hormone

UniProt ID

INS_BOVIN

GO ID	GO Term	Definition	Evidence
GO:0005623	Cellular Component	cell	IDA
GO:0005615	Cellular Component	extracellular space	IDA
GO:0042802	Molecular Function	identical protein binding	IPI
GO:0005158	Molecular Function	insulin receptor binding	IDA
GO:0035938	Biological Process	estradiol secretion	IDA	more>>
GO:0007631	Biological Process	feeding behavior	IDA
GO:0044381	Biological Process	glucose import in response to insulin stimulus	IDA
GO:0006006	Biological Process	glucose metabolic process	IEA
GO:0043066	Biological Process	negative regulation of apoptotic process	IMP
GO:0032099	Biological Process	negative regulation of appetite	IDA
GO:1903488	Biological Process	negative regulation of lactation	IDA
GO:0050995	Biological Process	negative regulation of lipid catabolic process	IDA
GO:1903524	Biological Process	positive regulation of blood circulation	IDA
GO:1903431	Biological Process	positive regulation of cell maturation	IDA
GO:0010628	Biological Process	positive regulation of gene expression	IDA
GO:0032024	Biological Process	positive regulation of insulin secretion	IDA
GO:1903489	Biological Process	positive regulation of lactation	IDA
GO:0033601	Biological Process	positive regulation of mammary gland epithelial cell proliferation	IDA
GO:0090277	Biological Process	positive regulation of peptide hormone secretion	IDA
GO:0014068	Biological Process	positive regulation of phosphatidylinositol 3-kinase signaling	IDA
GO:0050714	Biological Process	positive regulation of protein secretion	IDA
GO:0035025	Biological Process	positive regulation of Rho protein signal transduction	IDA
GO:0009306	Biological Process	protein secretion	IMP
GO:1903544	Biological Process	response to butyrate	IDA
GO:0032094	Biological Process	response to food	IDA
GO:0009749	Biological Process	response to glucose	IMP
GO:0060416	Biological Process	response to growth hormone	IDA
GO:0009408	Biological Process	response to heat	IDA
GO:1903576	Biological Process	response to L-arginine	IDA
GO:0031667	Biological Process	response to nutrient levels	IDA	less<<

Modification

Length

Sequence

FVNQHLCGSH LVEALYLVCG ERGFFYTPKA

Properties

View

Structure

PDB	Method	Resolution	Chain	Position
1APH	X-ray	2.00 A	B	1-30
1BPH	X-ray	2.00 A	B	1-30
1CPH	X-ray	1.90 A	B	1-30
1DPH	X-ray	1.90 A	B	1-30
1HO0	NMR	-	A	1-30
1PID	X-ray	1.30 A	B/D	1-25
2A3G	X-ray	2.25 A	B/D	1-30
2BN1	X-ray	1.40 A	B	1-30
2BN3	X-ray	1.40 A	B	1-30
2INS	X-ray	2.50 A	B/D	2-30
2ZP6	X-ray	2.56 A	B/D	1-30
3W14	X-ray	4.40 A	B/J	1-30
4BS3	X-ray	2.30 A	B	1-30
4E7T	X-ray	1.40 A	B/D	1-30
4E7U	X-ray	1.30 A	B/D	1-30
4E7V	X-ray	1.80 A	2/4/6/B/D/F/H/J/L/N/P/R/T/V/X/Z	1-30
4I5Y	X-ray	1.80 A	B	1-30
4I5Z	X-ray	1.80 A	B	1-30
4IDW	X-ray	2.70 A	B/D	1-30
4IHN	X-ray	1.16 A	B	1-30
4M4F	X-ray	1.90 A	B/D	1-30
4M4H	X-ray	1.90 A	B/D	1-30
4M4I	X-ray	1.90 A	B/D	1-30
4M4J	X-ray	1.90 A	B/D	1-30
4M4L	X-ray	1.45 A	B/D	1-30
4M4M	X-ray	1.50 A	B/D	1-30
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DSSP

Helix (H, G, I): 46.67%

Beta strand (B, E): 3.33%

Turn (S, T): 16.67%

Coil (C): 33.33%

1 FVNQHLCGSH LVEALYLVCG ERGFFYTPKA
SS THH HHHHHHHHHG GG B TT

Pfam

Accession NO.	Identifier	Description
PF00049	Insulin	Insulin/IGF/Relaxin family

SCOP

Class	Fold	Superfamily	Family
Small proteins	Insulin-like	Insulin-like	Insulin-like

CATH