Bioactive peptide information

BP0991

Name

Prolactin

Organism

Homo sapiens

Family

somatotropin/prolactin family

Classification

Hormone

UniProt ID

PRL_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	TAS
GO:0005622	Cellular Component	intracellular	TAS
GO:0005148	Molecular Function	prolactin receptor binding	TAS
GO:0008283	Biological Process	cell proliferation	TAS
GO:0007166	Biological Process	cell surface receptor signaling pathway	TAS	more>>
GO:0044267	Biological Process	cellular protein metabolic process	TAS
GO:0007565	Biological Process	female pregnancy	NAS
GO:0060397	Biological Process	JAK-STAT cascade involved in growth hormone signaling pathway	TAS
GO:0007595	Biological Process	lactation	IEA
GO:0046427	Biological Process	positive regulation of JAK-STAT cascade	IDA
GO:0040014	Biological Process	regulation of multicellular organism growth	IEP	less<<

Modification

Modification	Residue	Position
Phosphoserine	Ser	26
Phosphoserine	Ser	34
Phosphoserine	Ser	90
Phosphoserine	Ser	135
Phosphoserine	Ser	166

Length

199

Sequence

LPICPGGAAR  CQVTLRDLFD  RAVVLSHYIH  NLSSEMFSEF  DKRYTHGRGF  ITKAINSCHT  SSLATPEDKE
QAQQMNQKDF  LSLIVSILRS  WNEPLYHLVT  EVRGMQEAPE  AILSKAVEIE  EQTKRLLEGM  ELIVSQVHPE
TKENEIYPVW  SGLPSLQMAD  EESRLSAYYN  LLHCLRRDSH  KIDNYLKLLK  CRIIHNNNC

Properties

View

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
1RW5	NMR	-	A	1-199
2Q98	X-ray	2.70 A	A	10-199
3D48	X-ray	2.50 A	P	12-199
3EW3	X-ray	3.80 A	A	11-199
3MZG	X-ray	2.10 A	A	15-199
3N06	X-ray	2.00 A	A	15-199
3N0P	X-ray	2.10 A	A	15-199
3NCB	X-ray	2.10 A	A	15-199
3NCC	X-ray	2.50 A	A	15-199
3NCE	X-ray	2.00 A	A	15-199
3NCF	X-ray	2.80 A	A	15-199
3NPZ	X-ray	3.35 A	A	1-199
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 61.81%

Beta strand (B, E): 0.00%

Turn (S, T): 18.59%

Coil (C): 19.60%

1    LPICPGGAAR  CQVTLRDLFD  RAVVLSHYIH  NLSSEMFSEF  DKRYTHGRGF  ITKAINSCHT
       SSSS  SS      HHHHHH  HHHHHHHHHH  HHHHHHHHHH  HTTTSTT SS  TTS     GG
61   SSLATPEDKE  QAQQMNQKDF  LSLIVSILRS  WNEPLYHLVT  EVRGMQEAPE  AILSKAVEIE
     GGS   SSHH  HHHHH STHH  HHHHHHHHHH  HHHHHHHHHH  HHHT SSSSS  HHHHHHHHHH
121  EQTKRLLEGM  ELIVSQVHPE  TKENEIYPVW  SGLPSLQMAD  EESRLSAYYN  LLHCLRRDSH
     HHHHHHHHHH  HHHHHHH TT   S             S TT     HHHHHHHHHH  HHHHHHHHHH
181  KIDNYLKLLK  CRIIHNNNC
     HHHHHHHHHH  HHHT SS

Pfam

Accession NO.	Identifier	Description
PF00103	Hormone_1	Somatotropin hormone family

SCOP

Class	Fold	Superfamily	Family
All alpha proteins	4-helical cytokines	4-helical cytokines	Long-chain cytokines

CATH

Class	Architecture	Topology	Homology
Mainly Alpha	Up-down Bundle	Growth Hormone; Chain: A;