Bioactive peptide information

BP0600

Name

Interleukin-17F

Organism

Homo sapiens

Family

IL-17 family

Classification

Cytokine/Growth factor

UniProt ID

IL17F_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	NAS
GO:0005615	Cellular Component	extracellular space	IBA
GO:0005125	Molecular Function	cytokine activity	IDA
GO:0019955	Molecular Function	cytokine binding	IDA
GO:0005126	Molecular Function	cytokine receptor binding	IBA	more>>
GO:0042803	Molecular Function	protein homodimerization activity	IDA
GO:0051216	Biological Process	cartilage development	IDA
GO:0007166	Biological Process	cell surface receptor signaling pathway	IBA
GO:0042089	Biological Process	cytokine biosynthetic process	IDA
GO:0006954	Biological Process	inflammatory response	IBA
GO:0042109	Biological Process	lymphotoxin A biosynthetic process	IDA
GO:0016525	Biological Process	negative regulation of angiogenesis	IDA
GO:1900017	Biological Process	positive regulation of cytokine production involved in inflammatory response	IEA
GO:2000778	Biological Process	positive regulation of interleukin-6 secretion	IEA
GO:0045944	Biological Process	positive regulation of transcription from RNA polymerase II promoter	IEA
GO:0045423	Biological Process	regulation of granulocyte macrophage colony-stimulating factor biosynthetic process	IDA
GO:0045076	Biological Process	regulation of interleukin-2 biosynthetic process	IDA
GO:0045408	Biological Process	regulation of interleukin-6 biosynthetic process	IDA
GO:0045414	Biological Process	regulation of interleukin-8 biosynthetic process	IDA
GO:0017015	Biological Process	regulation of transforming growth factor beta receptor signaling pathway	IDA	less<<

Modification

Length

133

Sequence

RKIPKVGHTF FQKPESCPPV PGGSMKLDIG IINENQRVSM SRNIESRSTS PWNYTVTWDP NRYPSEVVQA
QCRNLGCINA QGKEDISMNS VPIQQETLVV RRKHQGCSVS FQLEKVLVTV GCTCVTPVIH HVQ

Properties

View

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
1JPY	X-ray	2.85 A	A/B/X/Y	1-133
3JVF	X-ray	3.30 A	A/B	1-133
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DSSP

Helix (H, G, I): 7.30%

Beta strand (B, E): 44.53%

Turn (S, T): 20.44%

Coil (C): 27.74%

1    GSHMRKIPKV  GHTFFQKPES  CPPVPGGSMK  LDIGIINENQ  RVSMSRNIES  RSTSPWNYTV
                   GGG   TT  S   SSSEEE  EEEEEETTT        TTHHH  HBSS EEEEE
61   TWDPNRYPSE  VVQAQCRNLG  CINAQGKEDI  SMNSVPIQQE  TLVVRRKHQG  CSVSFQLEKV
     EE TTEESSE  EEEEEES SS  EE SSS EET  TSEEEEEEEE  EEEEEEESSG  GG EEEEEEE
121  LVTVGCTCVT  PVIHHVQ
     EEEEEEEEE

Pfam

Accession NO.	Identifier	Description
PF06083	IL17	Interleukin-17

SCOP

Class	Fold	Superfamily	Family
Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Interleukin 17F, IL-17F

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines