Bioactive peptide information

BP0592

Name

C-C motif chemokine 17

Organism

Homo sapiens

Family

intercrine beta (chemokine CC) family

Classification

Cytokine/Growth factor

UniProt ID

CCL17_HUMAN

GO ID	GO Term	Definition	Evidence
GO:0005576	Cellular Component	extracellular region	TAS
GO:0005615	Cellular Component	extracellular space	IBA
GO:0048020	Molecular Function	CCR chemokine receptor binding	IBA
GO:0008009	Molecular Function	chemokine activity	TAS
GO:0005102	Molecular Function	receptor binding	TAS	more>>
GO:0007267	Biological Process	cell-cell signaling	TAS
GO:0071346	Biological Process	cellular response to interferon-gamma	IBA
GO:0071347	Biological Process	cellular response to interleukin-1	IBA
GO:0071356	Biological Process	cellular response to tumor necrosis factor	IBA
GO:0070098	Biological Process	chemokine-mediated signaling pathway	IBA
GO:0006935	Biological Process	chemotaxis	TAS
GO:0007186	Biological Process	G-protein coupled receptor signaling pathway	TAS
GO:0006954	Biological Process	inflammatory response	IBA
GO:0048247	Biological Process	lymphocyte chemotaxis	IBA
GO:0002548	Biological Process	monocyte chemotaxis	IBA
GO:0007275	Biological Process	multicellular organism development	TAS
GO:0045662	Biological Process	negative regulation of myoblast differentiation	IEA
GO:0030593	Biological Process	neutrophil chemotaxis	IBA
GO:0070374	Biological Process	positive regulation of ERK1 and ERK2 cascade	IBA
GO:0043547	Biological Process	positive regulation of GTPase activity	IBA	less<<

Modification

Length

Sequence

ARGTNVGREC CLEYFKGAIP LRKLKTWYQT SEDCSRDAIV FVTVQGRAIC SDPNNKRVKN AVKYLQSLER
S

Properties

View

Disulfide bond

Structure

PDB	Method	Resolution	Chain	Position
1NR2	X-ray	2.18 A	A/B	1-71
1NR4	X-ray	1.72 A	A/B/C/D/E/F/G/H	1-71
Jmol._Canvas2D (Jmol) "jmolApplet0"[x]			spin cartoon wire ball&stick spacefill

DSSP

Helix (H, G, I): 15.49%

Beta strand (B, E): 21.13%

Turn (S, T): 26.76%

Coil (C): 36.62%

1    ARGTNVGREC  CLEYFKGAIP  LRKLKTWYQT  SEDCSRDAIV  FVTVQGRAIC  SDPNNKRVKN
                  SS   S     TTTEEEEEE    TTSSS  EE  EEETTS EEE  E TTSHHHHH
61   AVKYLQSLER  S
     HHHHHHTT

Pfam

Accession NO.	Identifier	Description
PF00048	IL8	Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP

Class	Fold	Superfamily	Family
Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines

CATH

Class	Architecture	Topology	Homology
Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)